Intubation Attempts Increase the Risk for Severe Intraventricular Hemorrhage in Preterm Infants-A Retrospective Cohort Study

Autor: Neil N. Finer, Yvonne E. Vaucher, James A. Proudfoot, Juin Yee Kong, Mallory A. Boutin, Charles W. Sauer, Tina A. Leone
Rok vydání: 2016
Předmět:
Zdroj: The Journal of pediatrics. 177
ISSN: 1097-6833
Popis: To evaluate whether neonates exposed to multiple intubation attempts within the first 4 days after birth have an increased incidence of intraventricular hemorrhage (IVH).This is a retrospective cohort study of infants intubated during the first 4 days after birth. Infants had birth weights (BWs) less than 1500 g and were admitted to the neonatal intensive care unit (NICU) at the University of California, San Diego, between January 1, 2005, and July 30, 2009. A subgroup analysis was done for infants with BW less than 750 g.A total of 308 infants with BW 1500 g, including 102 with a BW750 g, were intubated within the first 4 days of life. The number of intubation attempts was significantly greater in infants with a BW750 g who had severe IVH compared with those with mild or no IVH (OR 1.395, 95% CI 1.090-1.786, P = .008). For infants with BW1500 g, the number of intubation attempts in the delivery room was significantly greater for infants with severe IVH (OR 1.317, 95% CI 1.052-1.649, P = .016).Increased intubation attempts were associated with increased incidence of severe IVH in infants with BW less than 750 g and in infants less than 1500 g who were intubated only in the delivery room. Prospective studies are needed to further evaluate the relationship between intubation attempts and severe IVH.
Databáze: OpenAIRE