Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation

Autor:	Naofumi Yoshida, Koji Fukuzawa, Hideya Suehiro, Tomoya Yamashita, Hiroyuki Takahara, Yu Izawa, Yoshiaki Watanabe, Yusuke Sonoda, Toshihiro Nakamura, Kyoko Yamamoto, Makoto Takemoto, Tomomi Akita, Jun Sakai, Ken-ichi Hirata, Mitsuru Takami, Kunihiko Kiuchi, Kazutaka Nakasone, Atsusuke Yatomi
Rok vydání:	2021
Předmět:	medicine.medical_specialty medicine.medical_treatment CD14 Contrast Media Gadolinium Catheter ablation 030204 cardiovascular system & hematology Monocytes 03 medical and health sciences 0302 clinical medicine Recurrence hemic and lymphatic diseases Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Heart Atria cardiovascular diseases 030212 general & internal medicine Univariate analysis medicine.diagnostic_test Receiver operating characteristic Surrogate endpoint business.industry Magnetic resonance imaging Atrial fibrillation Atrial Remodeling Ablation medicine.disease Magnetic Resonance Imaging Catheter Ablation Cardiology Cardiology and Cardiovascular Medicine business human activities
Zdroj:	Journal of Cardiovascular Electrophysiology. 32:1035-1043
ISSN:	1540-8167 1045-3873
DOI:	10.1111/jce.14929
Popis:	Background Inflammation, such as that associated with intermediate CD14++ CD16+ monocytes and atrial structural remodeling (SRM), may be important in the recurrence of atrial fibrillation (AF) after catheter ablation. However, the relationship between the intermediate CD14++ CD16+ monocytes, SRM, and AF recurrence is unclear. Methods Twenty-four patients with AF were enrolled. The proportion of intermediate monocytes (PIM) was assessed before ablation by flow cytometry. As a surrogate marker of SRM, the volume ratio (VR) of signal intensity greater than 1 standard deviation on late-gadolinium enhancement magnetic resonance imaging (LGE-MRI) was calculated. We investigated whether PIM correlated with SRM on LGE-MRI and determined the optimal cutoff value for predicting AF recurrence. Results Univariate analysis revealed positive correlations between PIM and BNP with SRM (PIM: r = .593, p = .002; BNP: r = .567, p = .004). Multivariable analysis revealed that PIM was independently associated with VR on LGE-MRI (β = .522; p = .033). The finding of an area under the receiver operating characteristic curve of 0.750 revealed that a VR ≥ 13.3% on LGE-MRI as the optimal cutoff value to predict AF recurrence with 80% sensitivity and 71% specificity, which was associated with PIM ≥ 10.0%. Conclusion Intermediate monocytes were significantly positively correlated with SRM. PIM ≥ 10% was associated with a VR ≥ 13.3% on LGE-MRI, which predicted AF recurrence after catheter ablation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8b385d73b8aca047f6cd2ed16d9374 https://doi.org/10.1111/jce.14929 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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