Induction of the SOS response in Escherichia coli by heavy ions
| Autor: | M. Bonev, I. Soska, K.G. Amirtayev, Evgeny Krasavin, S. Kozubek, V. Drasil, B. Tokarova |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
DNA Repair
Health Toxicology and Mutagenesis medicine.disease_cause Ion Microbiology Ionizing radiation chemistry.chemical_compound Genetics medicine Escherichia coli SOS response Cobalt Radioisotopes SOS Response Genetics Molecular Biology biology Mutagenesis Dose-Response Relationship Radiation biochemical phenomena metabolism and nutrition biology.organism_classification Alkaline Phosphatase beta-Galactosidase Enterobacteriaceae SOS chromotest Kinetics chemistry Cesium Radioisotopes Gamma Rays Genes Bacterial Biophysics bacteria DNA |
| Zdroj: | Mutation research. 215(1) |
| ISSN: | 0027-5107 |
| Popis: | The effectiveness of heavy ions in inducing the SOS response in E. coli cells has been measured by means of the SOS-chromotest. The SOS induction potency of ionizing radiation increases with increasing LET, to 40–60 keV/μm, reaches a maximum and then decreases at greater LET values. We conclude that the SOS-inducing damages in the case of ionizing radiation could be DNA injuries of a ‘complex’ type, e.g., DNA double-strand breaks or some kind of heavily damaged single-strand lesions. |
| Databáze: | OpenAIRE |
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