Peripheral neuropathy: an important contributor to physical limitation and morbidity in stages 3 and 4 chronic kidney disease
| Autor: | Arun V. Krishnan, Adrienne Kirby, Caoimhe M K Scales, Timothy J. Pianta, Tushar Issar, Zoltan H. Endre, Natalie Kwai, Ria Arnold |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Transplantation medicine.medical_specialty business.industry Diabetes status Peripheral Nervous System Diseases medicine.disease Preferred walking speed Physical limitations Peripheral neuropathy Quality of life Nephrology Internal medicine medicine Quality of Life Humans Observational study Female Stage (cooking) Morbidity Renal Insufficiency Chronic business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 37(4) |
| ISSN: | 1460-2385 |
| Popis: | Background Impaired physical function drives adverse outcomes in chronic kidney disease (CKD). Peripheral neuropathy is highly prevalent in CKD, though its contribution to physical function in CKD patients is unknown. This study examined the relationships between peripheral neuropathy, walking speed and quality of life (QoL) in stages 3 and 4 CKD. Methods This was a prospective observational study investigating neuropathy in CKD patients with an estimated glomerular filtration rate (eGFR) 15–60 mL/min/1.73 m2. A total of 109 patients were consecutively recruited. The presence and severity of peripheral neuropathy was determined using the total neuropathy score. Walking speed was assessed at both usual and maximal speed, and QoL was assessed using the Short- Form 36 (SF-36) questionnaire. Results Peripheral neuropathy was highly prevalent: 40% demonstrated mild neuropathy and 37% had moderate–severe neuropathy. Increasing neuropathy severity was the primary predictor of reduced walking speed (R2 = −0.41, P Conclusions Moderate to severe peripheral neuropathy was common in stages 3 and 4 CKD, associated with reduced walking speed independent of diabetes status and was correlated with patient-reported QoL. This suggests that neuropathy is an important contributor to declining physical function in CKD irrespective of diabetes status. Targeted diagnosis and management of peripheral neuropathy during CKD progression may improve functional outcomes and QoL. |
| Databáze: | OpenAIRE |
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