MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes
| Autor: | Pedro Díaz-Pozo, Miguel Martí, Milagros Rocha, Victor M. Victor, Teresa Vezza, Nadezda Apostolova, Francisco Canet, Aranzazu M. de Marañón, Pilar D'Ocon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology medicine.medical_treatment Clinical Biochemistry Inflammation RM1-950 Type 2 diabetes Review Biology medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Insulin resistance microRNA medicine oxidative stress redox signaling Molecular Biology Insulin Cell Biology medicine.disease Cell biology Crosstalk (biology) 030104 developmental biology 030220 oncology & carcinogenesis Therapeutics. Pharmacology type 2 diabetes medicine.symptom Signal transduction Oxidative stress |
| Zdroj: | Antioxidants Antioxidants, Vol 10, Iss 802, p 802 (2021) |
| ISSN: | 2076-3921 |
| Popis: | Type 2 diabetes is a chronic disease widespread throughout the world, with significant human, social, and economic costs. Its multifactorial etiology leads to persistent hyperglycemia, impaired carbohydrate and fat metabolism, chronic inflammation, and defects in insulin secretion or insulin action, or both. Emerging evidence reveals that oxidative stress has a critical role in the development of type 2 diabetes. Overproduction of reactive oxygen species can promote an imbalance between the production and neutralization of antioxidant defence systems, thus favoring lipid accumulation, cellular stress, and the activation of cytosolic signaling pathways, and inducing β-cell dysfunction, insulin resistance, and tissue inflammation. Over the last few years, microRNAs (miRNAs) have attracted growing attention as important mediators of diverse aspects of oxidative stress. These small endogenous non-coding RNAs of 19–24 nucleotides act as negative regulators of gene expression, including the modulation of redox signaling pathways. The present review aims to provide an overview of the current knowledge concerning the molecular crosstalk that takes place between oxidative stress and microRNAs in the physiopathology of type 2 diabetes, with a special emphasis on its potential as a therapeutic target. |
| Databáze: | OpenAIRE |
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