Orally administered β-glucan improves the hemolytic activity of the complement system in horses
| Autor: | Luiz Carlos Kreutz, Lucas de Figueiredo Soveral, João Antônio Guizzo, Luana Marina Scheer Erpen, Yasmin Kreutz, Rovian Miotto, Taline Scalco Picetti, Rafael Frandoloso |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
040301 veterinary sciences
Veterinary medicine Physiology muramidase SF1-1100 0403 veterinary science 03 medical and health sciences Classical complement pathway Immune system SF600-1100 Medicine 030304 developmental biology 0303 health sciences Innate immune system General Veterinary business.industry Monocyte Horse 04 agricultural and veterinary sciences Acquired immune system Animal culture Respiratory burst Complement system animals medicine.anatomical_structure glucans business monocytes Research Article |
| Zdroj: | Veterinary World Veterinary World, Vol 14, Iss 4, Pp 835-840 (2021) |
| ISSN: | 2231-0916 0972-8988 |
| Popis: | Background and Aim: Immune-modulating molecules mainly act on innate immune cells, which are central to early defense against invading pathogens and contribute to developing adaptive immunity. Yeast-extracted β-glucan, a model immune-modulating molecule, is widely used in several animal species; however, its effect on horse immune parameters has not been thoroughly investigated yet. This study aimed to evaluate the effects of orally administered β-glucan on selected innate immune parameters in horses. Materials and Methods: Eighteen thoroughbred horses were assigned equally into three groups as follows: One control group (no β-glucan) and two β-glucan experimental groups (one received 125 mg and the other 2 g of β-glucan per day for 28 days). Blood samples were collected before and at the end of the experiment for hematological analysis, whole blood phagocytosis, respiratory burst assays, and to assess the serum lysozyme and complement hemolytic activities. Results: At the end of the experiment, significant decreases (p |
| Databáze: | OpenAIRE |
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