Cardiovascular effects of fentanyl in conscious rats

Autor: Didier Gasser, François Baechtold, Cláudia Cavadas, Kirk L. Peterson, Eric Grouzmann, Michèle Markert, François Feihl, Bernard Waeber
Rok vydání: 2001
Předmět:
Male
Cardiac output
Physiology
Clinical Biochemistry
Acetylcholine/pharmacology Analgesia Analgesics
Opioid/administration & dosage/*pharmacology Animals Aorta/drug effects/physiology Blood Pressure/drug effects Cardiac Output/drug effects Cardiovascular System/*drug effects Fentanyl/administration & dosage/*pharmacology Heart Rate/drug effects Male Norepinephrine/blood/pharmacology Rats Rats
Wistar Vasodilation/drug effects
Blood Pressure
Cardiovascular System
Fentanyl
Norepinephrine
Heart Rate
Physiology (medical)
Heart rate
Medicine
Animals
Cardiac Output
Rats
Wistar
Aorta
business.industry
medicine.disease
Acetylcholine
Rats
Analgesics
Opioid
Vasodilation
Blood pressure
Anesthesia
Shock (circulatory)
Respiratory alkalosis
Ventricular pressure
medicine.symptom
Analgesia
business
Vasoconstriction
medicine.drug
Zdroj: Pflügers Archiv : European Journal of Physiology, vol. 443, no. 1, pp. 155-162
ISSN: 0031-6768
Popis: The polymicrobial sepsis induced by cecal ligation and puncture (CLP) in the rat is widely used in shock research. For ethical reasons, narcotic analgesics are often administered in this model, with the potential risk of confounding effects. In conscious non-septic rats, we investigated the cardiovascular effects of a continuous i.v. infusion of fentanyl (20 microg/kg per h) administered with fluid loading (10 ml/kg per h) for 24 h, a regimen commonly applied in rat CLP. Animals were randomly allocated to receive analgesia with fluid loading (Fentanyl group), or fluid loading alone (Control). All endpoints were assessed after 24 h of infusion. At that time, Control animals had mild respiratory alkalosis, which was essentially abolished by fentanyl. Analgesia mildly elevated the plasma norepinephrine levels [median (interquartile range): Control 232 pg/ml (0-292), Fentanyl 302 pg/ml (234-676), P=0.045] but was devoid of any effect on blood pressure, heart rate, cardiac output (mean +/-SD: Control 388+/-61 ml/kg per min, Fentanyl 382+/-62 ml/kg per min, P=0.87) and indices of left ventricular function derived from high-fidelity recordings of left ventricular pressure (dP/dtmax: Control 11782+/-2324 mmHg/s, Fentanyl 12107+/-2816 mmHg/s, P=0.77). In ex vivo experiments carried out immediately after animal sacrifice, no differences were noted between the Control and Fentanyl groups in the sensitivity of endothelium-intact aortic rings to norepinephrine-induced vasoconstriction (-logEC50: Control 8.78+/-0.28, Fentanyl 8.83+/-0.26, P=0.52) or acetylcholine-induced vasodilatation (-logEC50: Control 7.00+/-0.37, Fentanyl 7.06+/-0.26+/-0.53, P=0.75). In conclusion, the present data provide no contraindication, and even some support for the ethical use of a high dose i.v. infusion of fentanyl in cardiovascular studies of conscious catheterized rats undergoing CLP or other painful procedures.
Databáze: OpenAIRE
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