Expression of insulin-like growth factor 1 in sarcomas
| Autor: | I. Prinsen, A. Skottner, W. Den Otter, Jan A. M. Van Unnik, Cornelis J.M. Lips, P. J. M. Roholl |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Histology medicine.medical_treatment Cell Biology Desmin Pathology and Forensic Medicine Insulin-like growth factor Smooth muscle Somatomedins Malignant Fibrous Histiocytomas Biomarkers Tumor medicine Humans Angiosarcoma Insulin-Like Growth Factor I Actin Histiocytoma Benign Fibrous Sarcoma General Medicine medicine.disease Immunohistochemistry Actins medicine.anatomical_structure Palmar Fibromatosis |
| Zdroj: | Histopathology. 16:455-460 |
| ISSN: | 0309-0167 |
| DOI: | 10.1111/j.1365-2559.1990.tb01544.x |
| Popis: | The expression of insulin-like growth factor-1 (IGF-1) was studied in normal tissues, in eight benign lesions and in 50 sarcomas. In palmar fibromatosis the spindle cells in cell-dense areas exhibited a strong immunoreactivity. IGF-1 was variably found in leiomyosarcomas (7/8), malignant schwannomas (7/9), synovial sarcomas (2/3), liposarcomas (3/6), fibrosarcomas (1/3), malignant fibrous histiocytomas (10/18) and in one angiosarcoma. Two rhabdomyosarcomas failed to express IGF-1 and only the spindle cell component of synovial sarcomas was positive. Immunoreactivity for IGF-1 in 10 malignant filrous histiocytomas (MFH) appeared to be related to co-expression of smooth muscle actin. These findings imply that MFHs can be subdivided into a group of tumours which are devoid of morphological and immunophenotypic evidence of differentiation and a group which manifest immunophenotypic differentiation. |
| Databáze: | OpenAIRE |
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