Urinary cytokines in Schistosoma haematobium-infected schoolchildren from Tana Delta District of Kenya
| Autor: | Kimani Gachuhi, Birgitte J. Vennervald, Walter Jaoko, Benson B. Estambale, Dunstan A. Mukoko, Kariuki Njaanake, Paul E. Simonsen, Claus M. Reimert |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Adolescent Urinary system Enzyme-Linked Immunosorbent Assay Schistosomiasis Urine Gastroenterology Schistosomiasis haematobia Medical microbiology Internal medicine parasitic diseases medicine Animals Humans Child Parasite Egg Count Hematuria Inflammation Schistosoma haematobium Eosinophil cationic protein biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Venous blood medicine.disease biology.organism_classification Kenya Interleukin-10 Praziquantel Cross-Sectional Studies Infectious Diseases Child Preschool Immunology Cytokines Female business Research Article medicine.drug |
| Zdroj: | Njaanake, K H, Simonsen, P E, Vennervald, B J, Mukoko, D A, Reimert, C M, Gachuhi, K, Jaoko, W G & Estambale, B B 2014, ' Urinary cytokines in Schistosoma haematobium-infected schoolchildren from Tana Delta District of Kenya ', B M C Infectious Diseases, vol. 14, 501 . https://doi.org/10.1186/1471-2334-14-501 BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-14-501 |
| Popis: | Background Pathological changes due to infection with Schistosoma haematobium include cytokine-mediated urinary tract inflammation. The involved cytokines may be excreted in urine and their presence in urine may therefore reflect S. haematobium-related urinary tract pathology. The present study, for the first time, reports on the relationship between selected cytokines in urine and infection with S. haematobium in children from an area highly affected by this parasite. Methods Children aged 5–12 years from two primary schools in Tana Delta District of Kenya were examined for S. haematobium eggs using urine filtration technique, for haematuria using dipstix and for eosinophil cationic protein (ECP), IL-6, IFN- γ, TNF-α and IL-10 levels using ELISA, and for S. haematobium-related urinary tract pathology using ultrasonography. In addition, venous blood was examined for serum IL-6, IFN- γ, TNF-α and IL-10 levels using ELISA. Results There was no significant correlation between urinary and serum levels of IL-6, IFN- γ, TNF-α or IL-10. There was no significant difference in geometric mean intensity (GMI) in any of the serum cytokines, or in urinary TNF-α or IFN-γ, between children with light and heavy S. haematobium infections. However, children with heavy S. haematobium infections had significantly higher GMI of urinary IL-6 (p |
| Databáze: | OpenAIRE |
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