Prevalence of antibodies to recombinant virion infectivity factor in the sera of prospectively studied patients with HIV-1 infection
| Autor: | S. Schwander, R. W. Braun, U. Wieland, F. T. Hufert, M. Dietrich, P. Kern, J. E. Kühn |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Time Factors viruses HIV Infections HIV Antibodies Virus law.invention Immune system law Virology Immunopathology HIV Seropositivity Humans Prospective Studies Infectivity biology virus diseases biochemical phenomena metabolism and nutrition Infectious Diseases Immunology Humoral immunity HIV-1 Recombinant DNA biology.protein Viral disease Antibody Biomarkers |
| Zdroj: | Journal of Medical Virology. 36:142-146 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Two hundred twenty-four sera were collected from 34 HIV-1 infected patients during an observation period of up to 4.5 years (109 patient years of observation). The sera were tested for the presence of antibodies against the HIV-1 virion infectivity factor (vif) protein. Thirty sera from 6 HIV-1 seronegative individuals served as negative controls. The sera were immunoblotted against a recombinant, prokaryotically expressed vif protein. The prevalence of anti-vif antibodies increased significantly with progression of the disease from 18% to 81% (P less than 0.0001) which suggests a possible role of vif in HIV-1 replication and pathogenicity. |
| Databáze: | OpenAIRE |
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