Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
| Autor: | S. Wasef, K. R. Murray, Heather Edgell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cardiac output medicine.medical_specialty Middle Cerebral Artery Physiology medicine.medical_treatment Science Blood Pressure Pressoreceptors Hypoxic ventilatory response 030204 cardiovascular system & hematology Bed rest Article Head-Down Tilt Hypercapnia 03 medical and health sciences Young Adult 0302 clinical medicine Medical research Heart Rate Internal medicine medicine Tidal Volume Humans Hypoxia Pulse wave velocity Tidal volume Multidisciplinary business.industry Respiration Stroke Volume Cerebral blood flow Breathing Cardiology Medicine Female Vascular Resistance medicine.symptom business 030217 neurology & neurosurgery Bed Rest Neuroscience |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Head-down bed rest (HDBR) has previously been shown to alter cerebrovascular and autonomic control. Previous work found that sustained HDBR (≥ 20 days) attenuates the hypercapnic ventilatory response (HCVR); however, little is known about shorter-term effects of HDBR nor the influence of HDBR on the hypoxic ventilatory response (HVR). We investigated the effect of 4-h HDBR on HCVR and HVR and hypothesized attenuated ventilatory responses due to greater carotid and brain blood flow. Cardiorespiratory responses of young men (n = 11) and women (n = 3) to 5% CO2 or 10% O2 before and after 4-h HDBR were examined. HDBR resulted in lower HR, lower cardiac output index, lower common carotid artery flow, higher SpO2, and higher pulse wave velocity. After HDBR, tidal volume and ventilation responses to 5% CO2 were enhanced (all P 0.05). Short-duration HDBR does not alter the HVR, yet enhances the HCVR, which we hypothesize is a consequence of cephalic CO2 accumulation from cerebral congestion. |
| Databáze: | OpenAIRE |
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