Aspartame's effects on behavioral thermoregulation in albino rats
| Autor: | Andrea C. Rockwell, William F. Vitulli, Caprice Benoit, Charles R. Granade, Joseph M. Quinn, Janet E. McAleer, Deborah L. Parman |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Reinforcement Schedule Experimental and Cognitive Psychology 050105 experimental psychology Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animal science Animals Humans 0501 psychology and cognitive sciences Sugar Reinforcement Aspartame Saline control Appetitive Behavior Dose-Response Relationship Drug Chemistry 05 social sciences 030229 sport sciences Thermoregulation Sweetness Sensory Systems Rats Sprague dawley Dose–response relationship Female Injections Intraperitoneal Body Temperature Regulation |
| Zdroj: | Perceptual and motor skills. 83(1) |
| ISSN: | 0031-5125 |
| Popis: | Aspartame (L-aspartyl-L-phenylalanine methyl ester) was administered intraperitoneally to 9 Sprague-Dawley rats partitioned into 2 studies (4 in Study 1 and 5 for a replication in Study 2) over a two-year period using a within-subjects, repeated-measures reversal design Behavioral thermoregulation was assessed in a cold Skinner Box using 5-sec. exposures of microwave radiation [Specific Absorption Rate = 0.34 Watts/kg/(mW/cm2)] as reinforcing stimuli under a fixed-interval 2-min. schedule of positive reinforcement. Two factorial analyses of variance [5 (doses) × 8 (hours)] indicated that the main effect for the doses of aspartame (2, 4, 8, 16 mg/kg, and saline control) was not significant; yet, the interaction (dose × hours) was significant (p |
| Databáze: | OpenAIRE |
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