Chronopharmacology of the alpha-lipoic acid/nifedipine/glimepiride combination in the amelioration of retinopathy in rats
| Autor: | Michael Ikechukwu Oraebosi, M. Bisalla, Sherifat Bola Anafi, Temidayo Olutoyin Olurishe |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Nifedipine
Physiology Alpha-Lipoic Acid 030209 endocrinology & metabolism Pharmacology Antioxidants Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Physiology (medical) Animals Medicine Diabetic Retinopathy Thioctic Acid business.industry Drug administration Diabetic retinopathy medicine.disease Circadian Rhythm Rats Oxidative Stress Glimepiride Sulfonylurea Compounds lipids (amino acids peptides and proteins) business 030217 neurology & neurosurgery medicine.drug Retinopathy |
| Zdroj: | Chronobiology International. 38:443-450 |
| ISSN: | 1525-6073 0742-0528 |
| DOI: | 10.1080/07420528.2020.1866004 |
| Popis: | Time of drug administration affects both the kinetics and dynamics of medications. This study investigated diurnal efficacy of alpha-lipoic acid (ALA), nifedipine, and glimepiride combination in the treatment of diabetic retinopathy. The study design comprised seven groups of rats, with groups 1 and 2 serving as non-diabetic and diabetic controls, respectively, receiving 1 ml/kg distilled water. All other groups were diabetic, and received 10 mg/kg glimepiride at 20:00 h. Groups 4-7 also received 20 mg/kg nifedipine at 08:00 h. In addition, groups 5-7 received 100 mg/kg ALA at 08:00 h, 14:00 h, and 20:00 h, respectively. Oral drug administration was for 28 days during which fasting and random blood glucose sampling were done weekly at 07:30 h and 13:30 h, respectively. On the 29 |
| Databáze: | OpenAIRE |
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