Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation
| Autor: | Yasuhiko Tabata, Koichiro Nishiyama, Yutomo Seino, Hiromi Nagai, Makito Okamoto |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Larynx medicine.medical_specialty Basic fibroblast growth factor Vocal Cords Fibroblast growth factor Transplantation Autologous Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Paralysis Recurrent laryngeal nerve Animals Autologous transplantation Fascia 030223 otorhinolaryngology Denervation Recurrent Laryngeal Nerve business.industry Hydrogels Organ Size General Medicine Rats Surgery Fibroblast Growth Factors medicine.anatomical_structure Otorhinolaryngology chemistry Delayed-Action Preparations 030220 oncology & carcinogenesis Laryngeal Muscles medicine.symptom business Vocal Cord Paralysis |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 125:508-515 |
| ISSN: | 1943-572X 0003-4894 |
| Popis: | Objectives: Paralyzed tissue due to long-term denervation is resistant to many treatments because it induces irreversible histological changes and disorders of deglutition or phonation. We sought to determine the effect of autologous transplantation of fascia into the vocal fold (ATFV) with controlled release of basic fibroblast growth factor (bFGF) on long-term unilateral vocal fold paralysis (UVFP). Methods: Unilateral recurrent laryngeal nerve (RLN) section was performed on 20 rats. Five rats were implanted with autologous fascia only (fascia group), and 10 rats were implanted with autologous fascia and a gelatin hydrogel sheet with 1 μg (1 μg bFGF + fascia group) or 0.1 μg (0.1 μg bFGF + fascia group) of bFGF 4 months after RLN section. We evaluated the normalized glottal gap and laryngeal volume and histological changes 3 months after implantation. Results: The normalized glottal gap was significantly reduced in the 3 fascia implantation groups. Normalized laryngeal volume, fat volume, and lateral thyroarytenoid muscle volume were significantly increased in the 2 fascia implantation with bFGF groups. Conclusions: The ATFV with controlled release of bFGF repaired the glottal gap and laryngeal volume after RLN section and may reduce the occurrence of aspiration and hoarseness. We speculate that this treatment improves laryngeal function in long-term RLN denervation. |
| Databáze: | OpenAIRE |
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