Exhaled carbon monoxide in adolescents with diabetic cardiovascular autonomic neuropathy
| Autor: | Peter Ďurdík, Jarmila Vojtková, Miriam Ciljakova, Zuzana Michnová, Tomáš Turčan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Adolescent Endocrinology Diabetes and Metabolism Logistic regression Gastroenterology Young Adult chemistry.chemical_compound Endocrinology Diabetic Neuropathies Internal medicine parasitic diseases Humans Medicine Carbon Monoxide Type 1 diabetes business.industry Significant difference Healthy subjects food and beverages medicine.disease Surgery Diabetes Mellitus Type 1 Carboxyhemoglobin chemistry Pediatrics Perinatology and Child Health business Autonomic neuropathy Biomarkers |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 27 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2013-0401 |
| Popis: | The aim of the study was to determine if car- diovascular autonomic neuropathy (CAN) is associated with changed concentration of exhaled carbon monoxide (eCO) in adolescents with type 1 diabetes (T1D). A total of 46 T1D patients and 25 healthy controls (15 - 19 years) were enrolled. The parameters eCO and carboxyhemoglobin (HbCO) were established using a MICRO-4 Smokerlyser. CAN was examined by standard cardiovascular tests. Ado- lescents with T1D did not significantly differ in eCO com- pared to healthy subjects. eCO and HbCO were significantly lower in CAN-positive subjects (n = 19) (1.36 ± 1.65 ppm vs. 3.09 ± 2.31, p = 0.01 and 0.58 ± 0.49% vs. 1.04 ± 0.44, p < 0.01, respectively) compared to CAN-negative subjects (n = 27), whereas no significant difference was found in other measured parameters. By multivariate logistic regression, eCO and HbCO were associated with higher risk of CAN (OR = 1.824, p < 0.05 and OR = 10.989, p < 0.01). Our results indicate that eCO is decreased in CAN-positive diabetic subjects. Further studies are necessary to investigate the possible role of eCO as a marker for CAN. |
| Databáze: | OpenAIRE |
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