Chemokine receptor 4 expression is correlated with the occurrence and prognosis of gastric cancer

Autor: Jinshen Wang, Bo Sun, Leping Li, Hong-Chang Wang, Yang Li
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: FEBS Open Bio
FEBS Open Bio, Vol 10, Iss 6, Pp 1149-1161 (2020)
ISSN: 2211-5463
Popis: Gastric cancer (GC) is a common tumor with a low 5‐year survival rate. The chemokine receptor 4 (CXCR4) protein contributes to the progression and prognosis of GC, but the relationship between CXCR4 and immune infiltration, somatic copy number alteration (SCNA), tumor purity, tumor mutation burden (TMB), cytolytic activity (CYT), and drug sensitivity in GC is poorly understood. This study aimed to systematically explore the role of CXCR4 in GC. Microarray and RNA‐seq data were collected from the Gene Expression Omnibus and The Cancer Genome Atlas. Our analysis shows that CXCR4 is correlated with various types of immune cells. Patients with high CXCR4 expression had a higher fraction of B cells and CD8+ T cells, and a lower fraction of CD4+ T cells. In addition, high CXCR4 expression was associated with more advanced tumor stage, worse prognosis and higher stromal score, immune score, and cytolytic activity (P
CXCR4 is a chemokine receptor, which regulates tumor growth, proliferation, and metastasis in cancers. We found that gastric cancer patients with overexpression of CXCR4 had lower TMB, purity, higher CYT, and CD8 T‐cell infiltration. The patients also exhibited reduced sensitivity to 17‐AGG, trametinib, and docetaxel. Collectively, these findings suggest that patients with overexpression of CXCR4 have worse prognosis.
Databáze: OpenAIRE
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