Effects of vatinoxan on xylazine‐induced pulmonary alterations in sheep
| Autor: | Magdy Adam, Anna Meller, Ahmed G. Abu-Shahba, Jere Lindén, Marja Raekallio, Kati Salla, Bettina Mannerström, Riitta Seppänen-Kaijansinkko |
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| Přispěvatelé: | Production Animal Medicine, Veterinary Pathology and Parasitology, Veterinary Biosciences, Helsinki One Health (HOH), DAPHNE - Developing Assessment Practices in Higher Education, Teachers' Academy, Marja Raekallio / Principal Investigator, Equine and Small Animal Medicine, Departments of Faculty of Veterinary Medicine, Helsinki Institute of Life Science HiLIFE, Infra, Medicum, HUS Head and Neck Center, Department of Oral and Maxillofacial Diseases, Clinicum |
| Rok vydání: | 2021 |
| Předmět: |
sheep
Pentobarbital Respiratory rate cardiopulmonary effects 040301 veterinary sciences medicine.medical_treatment BLOOD-PRESSURE pathological alterations 413 Veterinary science DEXMEDETOMIDINE-INDUCED SEDATION xylazine 0403 veterinary science Xylazine 03 medical and health sciences 0302 clinical medicine Heart Rate 030202 anesthesiology medicine Animals Lung Saline 2. Zero hunger Pharmacology Detomidine General Veterinary business.industry MEDETOMIDINE vatinoxan 04 agricultural and veterinary sciences Medetomidine DOGS Blood pressure Oxygen Saturation 317 Pharmacy ALPHA-2-ADRENOCEPTOR ANTAGONIST DETOMIDINE Anesthesia BRADYCARDIA Premedication PERIPHERAL ALPHA(2)-ADRENOCEPTOR ANTAGONIST business CARDIOPULMONARY MK-467 Quinolizines medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 45:117-125 |
| ISSN: | 1365-2885 0140-7783 |
| Popis: | It was hypothesized that premedication with vatinoxan, a peripheral alpha(2)-adrenoceptor antagonist, would mitigate xylazine-induced pulmonary alterations in sheep. Fourteen adult sheep were allotted into two equal groups and premedicated with either vatinoxan (750 mu g/kg IV) or saline and sedated 10 min later with xylazine (500 mu g/kg IV). Arterial oxygen saturation (SpO(2)) was measured and respiratory rate (RR) counted at intervals. The sheep were euthanized with IV pentobarbital 10 min after xylazine administration. The severity of pulmonary parenchymal alterations was assessed and graded grossly and histologically and correlations of the morphological changes with SpO(2) evaluated. Following xylazine injection, SpO(2) was significantly higher and RR significantly lower with vatinoxan than with saline and the sheep administered vatinoxan exhibited significantly smaller quantities of tracheal foam than those receiving saline. No significant differences in macroscopic oedema scores were detected between treatments. In contrast, the vatinoxan-treated animals exhibited significantly graver microscopic interstitial alveolar oedema and haemorrhage than saline-treated animals. The histological severity scores did not correlate with changes in SpO(2). In conclusion, xylazine induced a marked reduction in SpO(2) which was abolished by the prior administration of vatinoxan. The histologically detected alterations after pentobarbital euthanasia with vatinoxan premedication need to be studied further. |
| Databáze: | OpenAIRE |
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