Polybrominated diphenyl ethers and decabromodiphenyl ethane in paired hair/serum and nail/serum from corresponding chemical manufacturing workers and their correlations to thyroid hormones, liver and kidney injury markers
| Autor: | Xuezhen Zhao, Melikedilnur Bekir, Dejun Wang, Yan Wang, Dong Yu, Yinglin Du, Zhixiong Shi, Tian Chen, Wenwen Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Thyroid Hormones Environmental Engineering 010504 meteorology & atmospheric sciences Globulin Bilirubin 010501 environmental sciences Kidney 01 natural sciences chemistry.chemical_compound Polybrominated diphenyl ethers Internal medicine Halogenated Diphenyl Ethers Environmental Chemistry Medicine Humans Waste Management and Disposal 0105 earth and related environmental sciences Flame Retardants Creatinine Triiodothyronine integumentary system biology business.industry Albumin Pollution Endocrinology medicine.anatomical_structure chemistry Liver Nails biology.protein Nail (anatomy) Uric acid business Biomarkers Bromobenzenes |
| Zdroj: | The Science of the total environment. 729 |
| ISSN: | 1879-1026 |
| Popis: | We detected the polybrominated diphenyl ethers (PBDEs) or decabromodiphenyl ethane (DBDPE) in paired hair-serum and nail-serum samples collected from the corresponding chemical manufacturing workers. The levels of decabrominated diphenyl ether (BDE-209) or DBDPE in the serum, hair and nail samples were all significantly higher than those reported in other studies, and the "work place" (pretreatment or posttreatment workshop) was the primary influencing factor that affected the levels of specific BFRs in vivo. For BDE-209 workers, the BDE-209 in both the hair and nail samples were significantly and positively related to the BDE-209 in the serum, indicating that both hair and nails can be used as noninvasive biomatrices to reflect internal exposure to BDE-209. In DBDPE workers, hair rather than nails was more suitable for use as a noninvasive biomatrix to infer the DBDPE exposure level. A series of serum biomarkers reflecting thyroid hormones and liver and kidney injuries were tested to calculate the correlations between hair or nail BFR levels and the levels of the biomatrices. The BDE-209 in the hair samples was significantly and positively correlated with the total protein (TP), and the nail BDE-209 level was significantly and positively related to the total bilirubin (TBIL), indirect bilirubin (IDBIL) and uric acid (UA). The DBDPE in hair was significantly and positively correlated with the thyroid hormones free triiodothyronine (fT3) and total triiodothyronine (tT3) and kidney injury markers, including blood urea nitrogen (BUN), creatinine (CRE) and cystatin C (Cys-C). In addition, the nail DBDPE levels were significantly and positively correlated with the albumin/globulin (A/G), BUN, CRE and Cys-C but negatively correlated with the TP and globulin (GLO). Our findings provide preliminary evidence that hair and nails can be used as noninvasive biomatrices for assessing internal BFR exposure and health damage in occupational workers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect