The Effect of Electronic Cigarette User Modifications and E-liquid Adulteration on the Particle Size Profile of an Aerosolized Product
| Autor: | Joseph B. McGee Turner, Haley A Mulder, Justin L. Poklis, Alphonse Poklis, Matthew S. Halquist, Jesse L Patterson, Leon Kosmider, Michelle R. Peace |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Glycerol Nicotine Science Pharmaceutical formulation Electronic Nicotine Delivery Systems Characterization and analytical techniques Article 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Ultrafine particle Humans Pharmacokinetics Particle Size Author Correction Aerosolization Aerosols Multidisciplinary Chromatography Smokers Chemistry Respiration Propylene Glycol Aerosol Bioavailability 030104 developmental biology Deposition (aerosol physics) Drug delivery Medicine Particle size 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Electronic cigarettes (e-cigarettes) are an alternate nicotine delivery system that generate a condensation aerosol to be inhaled by the user. The size of the droplets formed in the aerosol can vary and contributes to drug deposition and ultimate bioavailability in the lung. The growing popularity of e-cigarette products has caused an increase in internet sources promoting the use of drugs other than nicotine (DOTNs) in e-cigarettes. The purpose of this study was to determine the effect of various e-cigarette and e-liquid modifications, such as coil resistance, battery voltage, and glycol and drug formulation, on the aerosol particle size. E-liquids containing 12 mg/mL nicotine prepared in glycol compositions of 100% propylene glycol (PG), 100% vegetable glycerin (VG), or 50:50 PG:VG were aerosolized at three voltages and three coil resistances. Methamphetamine and methadone e-liquids were prepared at 60 mg/mL in 50:50 PG:VG and all e-liquids were aerosolized onto a 10 stage Micro-Orifice Uniform Deposit Impactor. Glycol deposition correlated with drug deposition, and the majority of particles centered between 0.172–0.5 μm in diameter, representing pulmonary deposition. The 100% PG e-liquid produced the largest aerosol particles and the 100% VG and 50:50 PG:VG e-liquids produced ultra-fine particles |
| Databáze: | OpenAIRE |
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