Synthesis Of Alpha-Alkylated Ketones Via Selective Epoxide Opening/Alkylation Reactions With Primary Alcohols
| Autor: | Sertaç Genç, Süleyman Gülcemal, Bekir Çetinkaya, Derya Gülcemal, Salih Günnaz |
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| Rok vydání: | 2021 |
| Předmět: |
Secondary
Anti-Markovnikov Alcohols chemistry.chemical_element Epoxide Rearrangement Alkylation 010402 general chemistry Ring (chemistry) Methylation 01 natural sciences Biochemistry Catalysis chemistry.chemical_compound Complexes Organic chemistry Terminal Epoxides Iridium Physical and Theoretical Chemistry Borrowing Hydrogen Primary (chemistry) 010405 organic chemistry Organic Chemistry Borrowing hydrogen Regioselective Isomerization 0104 chemical sciences chemistry C-C Catalyst Carbene |
| Popis: | A new method for converting terminal epoxides and primary alcohols into alpha-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product. TUBITAK [120Z818]; Ege University Scientific Research Projects Coordination [FDK2021-22946]; Turkish Academy of Science (TUBA) This work was supported by TUBITAK (120Z818) and Ege University Scientific Research Projects Coordination (FDK2021-22946). B.C. acknowledges the Turkish Academy of Science (TUBA) for the financial support. The authors also thank the Ege University Directorate of Library and Documentation, EGE-PIK, and Enago for providing editing services. |
| Databáze: | OpenAIRE |
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