The Role of the IL-6 Cytokine Family in Epithelial–Mesenchymal Plasticity in Cancer Progression

Autor: A. Abaurrea, María M. Caffarel, Angela M Araujo
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Epithelial-Mesenchymal Transition
QH301-705.5
medicine.medical_treatment
Inflammation
Review
migration
epithelial–mesenchymal transition
Catalysis
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Neoplasms
medicine
Animals
Humans
cancer
Epithelial–mesenchymal transition
Physical and Theoretical Chemistry
Biology (General)
Interleukin 6
Molecular Biology
QD1-999
Spectroscopy
IL-6
biology
Interleukin-6
Organic Chemistry
Oncostatin M
Cancer
epithelial–mesenchymal plasticity
General Medicine
medicine.disease
invasion
cytokines
Computer Science Applications
Chemistry
030104 developmental biology
Cytokine
oncostatin M (OSM)
030220 oncology & carcinogenesis
Cancer cell
biology.protein
Cancer research
medicine.symptom
Inflammation Mediators
Janus kinase
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 8334, p 8334 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development, wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in heterogeneous and dynamic populations of cells with mixed epithelial and mesenchymal characteristics, which are required for local invasion and metastatic dissemination. Cancer development is associated with an inflammatory microenvironment characterized by the accumulation of multiple immune cells and pro-inflammatory mediators, such as cytokines and chemokines. Cytokines from the interleukin 6 (IL-6) family play fundamental roles in mediating tumour-promoting inflammation within the tumour microenvironment, and have been associated with chronic inflammation, autoimmunity, infectious diseases and cancer, where some members often act as diagnostic or prognostic biomarkers. All IL-6 family members signal through the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway and are able to activate a wide array of signalling pathways and transcription factors. In general, IL-6 cytokines activate EMP processes, fostering the acquisition of mesenchymal features in cancer cells. However, this effect may be highly context dependent. This review will summarise all the relevant literature related to all members of the IL-6 family and EMP, although it is mainly focused on IL-6 and oncostatin M (OSM), the family members that have been more extensively studied.
Databáze: OpenAIRE
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