Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder: A longitudinal study. The Danish High Risk and Resilience Study – VIA 7 and VIA 11

Autor: Julie Marie Brandt, Nicoline Hemager, Maja Gregersen, Anne Søndergaard, Mette Falkenberg Krantz, Jessica Ohland, Martin Wilms, Sinnika Birkehøj Rohd, Carsten Hjorthøj, Lotte Veddum, Christina Bruun Knudsen, Anna Krogh Andreassen, Aja Greve, Katrine Søborg Spang, Camilla Austa Christiani, Ditte Ellersgaard, Birgitte Klee Burton, Ditte Lou Gantriis, Vibeke Bliksted, Ole Mors, Kerstin Jessica Plessen, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Anne Amalie Elgaard Thorup
Rok vydání: 2022
Předmět:
Zdroj: Brandt, J M, Hemager, N, Gregersen, M, Søndergaard, A, Falkenberg Krantz, M, Ohland, J, Wilms, M, Birkehøj Rohd, S, Hjorthøj, C, Veddum, L, Bruun Knudsen, C, Krogh Andreassen, A, Greve, A, Spang, K S, Christiani, C A, Ellersgaard, D, Klee Burton, B, Gantriis, D L, Bliksted, V, Mors, O, Plessen, K J, Møllegaard Jepsen, J R, Nordentoft, M & Elgaard Thorup, A A 2022, ' Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder : A longitudinal study. The Danish High Risk and Resilience Study – VIA 7 and VIA 11 ', British Journal of Clinical Psychology, vol. 61, no. 4, pp. 875-894 . https://doi.org/10.1111/bjc.12364
Brandt, J M, Hemager, N, Gregersen, M, Søndergaard, A, Falkenberg Krantz, M, Ohland, J, Wilms, M, Birkehøj Rohd, S, Hjorthøj, C, Veddum, L, Bruun Knudsen, C, Krogh Andreassen, A, Greve, A, Spang, K S, Christiani, C A, Ellersgaard, D, Klee Burton, B, Gantriis, D L, Bliksted, V, Mors, O, Plessen, K J, Møllegaard Jepsen, J R, Nordentoft, M & Elgaard Thorup, A A 2022, ' Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder : A longitudinal study. The Danish High Risk and Resilience Study-VIA 7 and VIA 11 ', British Journal of Clinical Psychology . https://doi.org/10.1111/bjc.12364
ISSN: 2044-8260
0144-6657
DOI: 10.1111/bjc.12364
Popis: OBJECTIVES: Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs).DESIGN: The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs.METHODS: A cohort of 512 children at FHR-SZ (N = 199), FHR-BP (N = 118), and PBCs (N = 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (N = 172), FHR-BP (N = 104), and PBCs (N = 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview.RESULTS: Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0-11 years) compared with PBCs (OR 2.082, 95%CI 1.223-3.545, p = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29-1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26-1.85; PBCs: observed mean: 0.99, 95%CI 0.82-1.17; p < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0-11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122-6.710, p < .001; FHR-BP: OR 3.602, 95%CI 1.913-6.783, p < .001).CONCLUSIONS: Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.
Databáze: OpenAIRE
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