Effect of polymerization tendency on haematological, rheological and clinical parameters in sickle cell anaemia
| Autor: | Constance Tom Noguchi, M. C. Sowter, John Stuart, C. Johnson, A. J. Girling, A.J. Keidan, S. M. E. Stevens |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Polymers Visual analogue scale Chemistry Hemoglobin Sickle Cell Hemoglobin A Anemia Sickle Cell Hematology Severity of Illness Index Oxygen Endocrinology medicine.anatomical_structure Rheology Polymerization Sickle haemoglobin Erythrocyte Deformability Internal medicine Fetal hemoglobin Immunology medicine Humans Erythrocyte deformability Fetal Hemoglobin |
| Zdroj: | British Journal of Haematology. 71:551-557 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1989.tb06316.x |
| Popis: | The polymerization tendency of sickle haemoglobin was estimated as a function of oxygen saturation in 30 patients with homozygous sickle cell anaemia. The deformability of their erythrocytes was also measured, by initial-flow-rate filtration at 37 degrees C through pores of 5 microns diameter, and clinical severity was assessed using a visual analogue scale. By means of partial correlation analysis, it was found that correlations between haematological, rheological, and clinical parameters in sickle cell anaemia could be explained on the basis of an association of each variable with polymerization tendency. Patients with the greatest tendency to form polymer had the least deformable erythrocytes and perceived their disease to be more severe as judged by the visual analogue scale. Polymer formation also appeared to be a determinant of the number of dense cells which, in turn, determine haemolytic rate and erythrocyte deformability. |
| Databáze: | OpenAIRE |
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