Wound-dressing materials with antibacterial activity from electrospun polyurethane–dextran nanofiber mats containing ciprofloxacin HCl
| Autor: | R. Nirmala, Gopalsamy Gnanasekaran, Mohamed H. El-Newehy, Afeesh Rajan Unnithan, Hak Yong Kim, Nasser A.M. Barakat, P.B. Tirupathi Pichiah, Che-Hun Jung, Youn-Soo Cha |
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| Rok vydání: | 2012 |
| Předmět: |
Polymers and Plastics
Polymers Polyurethanes Biocompatible Materials Mice chemistry.chemical_compound Ciprofloxacin 3T3-L1 Cells Polymer chemistry Electrochemistry Materials Chemistry Animals Cell Proliferation Polyurethane Wound Healing Bacteria Organic Chemistry Biomaterial Dextrans Fibroblasts Bandages Biodegradable polymer Electrospinning Anti-Bacterial Agents Membrane Dextran chemistry Chemical engineering Nanofiber Antibacterial activity |
| Zdroj: | Carbohydrate Polymers. 90:1786-1793 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2012.07.071 |
| Popis: | Dextran is a versatile biomacromolecule for preparing electrospun nanofibrous membranes by blending with either water-soluble bioactive agents or hydrophobic biodegradable polymers for biomedical applications. In this study, an antibacterial electrospun scaffold was prepared by electrospinning of a solution composed of dextran, polyurethane (PU) and ciprofloxacin HCl (CipHCl) drug. The obtained nanofiber mats have good morphology. The mats were characterized by various analytical techniques. The interaction parameters between fibroblasts and the PU-dextran and PU-dextran-drug scaffolds such as viability, proliferation, and attachment were investigated. The results indicated that the cells interacted favorably with the scaffolds especially the drug-containing one. Moreover, the composite mat showed good bactericidal activity against both of Gram-positive and Gram-negative bacteria. Overall, our results conclude that the introduced scaffold might be an ideal biomaterial for wound dressing applications. |
| Databáze: | OpenAIRE |
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