Ethchlorvynol (Placidyl)-induced pulmonary edema
| Autor: | William Richard Smith, Frederick L. Glauser, Alex Caldwell, Neal Olsher, Geoffrey S. Dolan, Harold Baer, Melvin Hoshiko |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Substance-Related Disorders Pulmonary Edema Body weight Polyethylene Glycols Dogs Ethchlorvynol Internal Medicine Medicine Animals Humans Lung Dose-Response Relationship Drug business.industry Hemodynamics General Medicine Organ Size Pulmonary edema medicine.disease Disease Models Animal Anesthesia Injections Intravenous Female business medicine.drug |
| Zdroj: | Annals of internal medicine. 84(1) |
| ISSN: | 0003-4819 |
| Popis: | Two patients experienced severe nonhemodynamic pulmonary edema following the intravenous injection of 25 and 40 mg/kg of body weight of ethchlorvynol (Placidyl). The pulmonary edema cleared rapidly. Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. Injection of polyethylene glycol, the vehicle in which ethchlorvynol is diluted, did not reproduce the syndrome. |
| Databáze: | OpenAIRE |
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