Acute exercise modulates cigarette cravings and brain activation in response to smoking-related images: an fMRI study
| Autor: | Kate Janse Van Rensburg, Timothy L. Hodgson, Abdelmalek Benattayallah, Adrian H. Taylor |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent media_common.quotation_subject Craving Physical exercise Neuropsychological Tests Audiology Nicotine Young Adult Reward medicine Humans Exercise Default mode network media_common Cross-Over Studies Fusiform gyrus medicine.diagnostic_test Smoking Brain Tobacco Use Disorder General Medicine Middle Aged Abstinence Magnetic Resonance Imaging Substance Withdrawal Syndrome Behavior Addictive Female Orbitofrontal cortex medicine.symptom Functional magnetic resonance imaging Psychology Neuroscience medicine.drug |
| Zdroj: | Psychopharmacology. 203:589-598 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-008-1405-3 |
| Popis: | Substances of misuse (such as nicotine) are associated with increases in activation within the mesocorticolimbic brain system, a system thought to mediate the rewarding effects of drugs of abuse. Pharmacological treatments have been designed to reduce cigarette cravings during temporary abstinence. Exercise has been found to be an effective tool for controlling cigarette cravings. The objective of this study is to assess the effect of exercise on regional brain activation in response to smoking-related images during temporary nicotine abstinence. In a randomized crossover design, regular smokers (n = 10) undertook an exercise (10 min moderate-intensity stationary cycling) and control (passive seating for same duration) session, following 15 h of nicotine abstinence. Following treatments, participants entered a functional Magnetic Resonance Imaging (fMRI) scanner. Subjects viewed a random series of smoking and neutral images for 3 s, with an average inter-stimulus-interval (ISI) of 10 s. Self-reported cravings were assessed at baseline, mid-, and post-treatments. A significant interaction effect (time by group) was found, with self-reported cravings lower during and following exercise. During control scanning, significant activation was recorded in areas associated with reward (caudate nucleus), motivation (orbitofrontal cortex) and visuo-spatial attention (parietal lobe, parahippocampal, and fusiform gyrus). Post-exercise scanning showed hypo-activation in these areas with a concomitant shift of activation towards areas identified in the ‘brain default mode’ (Broadmanns Area 10). The study confirms previous evidence that a single session of exercise can reduce cigarette cravings, and for the first time provides evidence of a shift in regional activation in response to smoking cues. |
| Databáze: | OpenAIRE |
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