Exercise Training for Improving Patient-Reported Outcomes in Patients With Advanced-Stage Cancer: A Systematic Review and Meta-Analysis
| Autor: | Xu Zhang, Zhitong Bing, Long Ge, Xiuxia Li, Hai-kun Ma, Bang-wei Wang, Yajing Chen, Ya Xiao, Tao-tao Guo, Xuemei Han, Kehu Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Palliative care Context (language use) Anxiety law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Quality of life law Neoplasms medicine Insomnia Humans 030212 general & internal medicine Patient Reported Outcome Measures Exercise General Nursing Fatigue business.industry Cancer medicine.disease Anesthesiology and Pain Medicine Strictly standardized mean difference 030220 oncology & carcinogenesis Meta-analysis Physical therapy Quality of Life Neurology (clinical) medicine.symptom business |
| Zdroj: | Journal of pain and symptom management. 59(3) |
| ISSN: | 1873-6513 |
| Popis: | Context Patients with advanced-stage cancer often suffer many physical and psychological symptoms. Exercise has been shown to improve quality of life (QoL), decrease cancer-related symptoms, and maintain or improve functional status in cancer survivors or patients with early stage cancer. However, the effect of exercise on these outcomes in patients with advanced-stage cancer is unclear. Objectives This meta-analysis aimed to assess the effectiveness of exercise interventions for patients with advanced-stage cancer in improving cancer-related symptoms and functional status outcomes. Methods We conducted a comprehensive literature search in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science from their inception to February 3, 2019, to include randomized controlled trials (RCTs) comparing exercise and usual care for improving outcomes in patients with advanced-stage cancer. Two reviewers independently screened the studies, extracted data of interest, and assessed the risk of bias of individual RCTs using the Cochrane Handbook, Version 5.1.0. Results About 15 RCTs enrolling 1208 patients were included. Compared with usual care, exercise showed a significant improvement in QoL (standardized mean difference [SMD] 0.22; 95% CI 0.06–0.38; P = 0.009), fatigue (SMD −0.25; 95% CI −0.45 to −0.04; P = 0.02), insomnia (SMD −0.36; 95% CI −0.56 to −0.17; P = 0.0002), physical function (SMD 0.22; 95% CI 0.05–0.38; P = 0.009), social function (SMD 0.18; 95% CI 0.02–0.34; P = 0.03), and dyspnea reduction (SMD −0.18; 95% CI −0.34 to −0.01; P = 0.03). Conclusion Exercise serves as an effective intervention to improve QoL and alleviate fatigue, insomnia, dyspnea, and physical and social functions for patients with advanced-stage cancer. |
| Databáze: | OpenAIRE |
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