Montreal cognitive assessment as a screening instrument for cognitive impairment in systemic lupus erythematosus patients without overt neuropsychiatric manifestations

Autor: Xin Rong Lim, Pamela Oi Khuan Chew, Gek Hsiang Lim, Yung Ling Low, June Wei Ping Lim, Huey Ni Ong, Weng Giap Law, Justina Wei Lynn Tan, Bernard YH Thong, Faith Li-Ann Chia, Tsui Yee Lian, Grace Yin Lai Chan, Madelynn Tsu-Li Chan, Ee Tzun Koh, Kok Ooi Kong, Hwee Siew Howe
Rok vydání: 2022
Předmět:
Zdroj: Lupus. 31:1759-1769
ISSN: 1477-0962
0961-2033
DOI: 10.1177/09612033221132237
Popis: Objectives The Montreal Cognitive Assessment (MoCA) is an increasingly used screening tool for cognitive impairment. The aim of this study was to examine how MoCA performed in identifying cognitive impairment (CI) domains in SLE patients compared with formal standardized neuropsychological testing (NPT). Factors related to SLE disease, immunologic and psychological state associated with CI were also explored. Methods This cross-sectional study recruited 50 SLE patients without overt neuropsychiatric manifestations from April 2017 to May 2018. The patients were evaluated with MoCA, formal NPT and the Depression, Anxiety, and Stress Scales (DASS) 42-item self-report questionnaire. Values of sensitivity and specificity were computed for different cut-offs of MoCA within each cognitive domain of NPT and descriptive analysis was used to identify the factors affecting cognitive function. Results The median score for MoCA was 27.5 (range 22–30). Using a MoCA cutoff of Conclusion MoCA may be a useful screening tool to identify the most frequently affected cognitive domain which is executive functioning using a lower cutoff of
Databáze: OpenAIRE
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