Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls
| Autor: | Elizabeth S. Lapadula, Joseph M. Massaro, Clara G. Zundel, Lisa Conboy, Kimberly Sullivan, Mohamed B. Abou-Donia, Nancy G. Klimas, Emily Quinn, Maria Abreu, Maxine Krengel, Daniel D. Nguyen, Efi Kokkotou, Jessica LeClair |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
CNS autoantibody Encephalomyelitis Central nervous system myalgic encephalomyelitis/chronic fatigue syndrome Gulf war Gastroenterology Article Gulf War illness lcsh:RC321-571 gender biomarkers proteins irritable bowel syndrome 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Chronic fatigue syndrome Diagnostic biomarker lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Irritable bowel syndrome 030304 developmental biology 0303 health sciences business.industry General Neuroscience Autoantibody medicine.disease humanities medicine.anatomical_structure Biomarker (medicine) business 030217 neurology & neurosurgery |
| Zdroj: | Brain Sciences, Vol 11, Iss 148, p 148 (2021) Brain Sciences; Volume 11; Issue 2; Pages: 148 Brain Sciences |
| ISSN: | 2076-3425 |
| Popis: | Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has not been an objective diagnostic biomarker. Recently, we reported on a newly developed blood biomarker that discriminates GWI from GW healthy controls, and symptomatic controls with irritable bowel syndrome (IBS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The present study was designed to compare levels of these biomarkers between men and women with GWI, as well as sex-specific effects in comparison to healthy GW veterans and symptomatic controls (IBS, ME/CFS). The results showed that men and women with GWI differ in 2 of 10 plasma autoantibodies, with men showing significantly elevated levels. Men and women with GWI showed significantly different levels of autoantibodies in 8 of 10 biomarkers to neuronal and glial proteins in plasma relative to controls. In summary, the present study addressed the utility of the use of plasma autoantibodies for CNS proteins to distinguish among both men and women veterans with GWI and other healthy and symptomatic control groups. |
| Databáze: | OpenAIRE |
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