Depression and Obesity: Analysis of Common Biomarkers
| Autor: | Anna Capasso, Maria Gabriella Foia, Paola Ambrosio, Valeria De Biasio, Walter Di Munzio, Walter Milano, Francesca Carizzone |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty obesity business.industry lcsh:R lcsh:Medicine biomarkers Review Bioinformatics medicine.disease Obesity Proinflammatory cytokine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Mood disorders Epidemiology depression Genetic predisposition Medicine business Socioeconomic status 030217 neurology & neurosurgery Depression (differential diagnoses) |
| Zdroj: | Diseases Diseases, Vol 8, Iss 23, p 23 (2020) |
| ISSN: | 2079-9721 |
| Popis: | Depression and obesity are very common pathologies. Both cause significant problems of both morbidity and mortality and have decisive impacts not only on the health and well-being of patients, but also on socioeconomic and health expenditure aspects. Many epidemiological studies, clinical studies and meta-analyses support the association between mood disorders and obesity in relationships to different conditions such as the severity of depression, the severity of obesity, gender, socioeconomic status, genetic susceptibility, environmental influences and adverse experiences of childhood. Currently, both depression and obesity are considered pathologies with a high-inflammatory impact; it is believed that several overlapping factors, such as the activation of the cortico-adrenal axis, the exaggerated and prolonged response of the innate immune system and proinflammatory cytokines to stress factors and pathogens—as well as alterations of the intestinal microbiota which promote intestinal permeability—can favor the expression of an increasingly proinflammatory phenotype that can be considered a key and common phenomenon between these two widespread pathologies. The purpose of this literature review is to evaluate the common and interacting mechanisms between depression and obesity. |
| Databáze: | OpenAIRE |
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