Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities
| Autor: | Petr Gál, Anika Kuczmannová, Silvia Fialová, Pavel Mučaji, Milan Nagy, Jaroslav Majernik, Racanská E, Miroslava Kameníková, Andrea Balažová |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
0301 basic medicine Pharmaceutical Science medicine.disease_cause Antioxidants Analytical Chemistry law.invention 0302 clinical medicine law Drug Discovery Butyrylcholinesterase biology Chemistry (miscellaneous) diabetes mellitus Agrimonia eupatoria Molecular Medicine artichoke medicine.drug medicine.medical_specialty Cynara 030209 endocrinology & metabolism Agrimonia streptozotocin phytotherapy agrimony Article Streptozocin Diabetes Mellitus Experimental lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry Internal medicine Diabetes mellitus medicine Animals Humans Hypoglycemic Agents Physical and Theoretical Chemistry Plant Extracts business.industry Body Weight Organic Chemistry Streptozotocin biology.organism_classification medicine.disease Rats 030104 developmental biology Endocrinology Gene Expression Regulation business Phytotherapy Oxidative stress |
| Zdroj: | Molecules; Volume 21; Issue 5; Pages: 564 Molecules Molecules, Vol 21, Iss 5, p 564 (2016) |
| ISSN: | 1420-3049 |
| Popis: | Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress. |
| Databáze: | OpenAIRE |
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