Antipsychotic-like activity of noni (Morinda citrifolia Linn.) in mice
| Autor: | Zahurin Mohamed, Vijayapandi Pandy, Megala Narasingam |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Apomorphine medicine.medical_treatment Dopamine Methamphetamine Mice Stereotypy Medicine Animals Humans Morinda Antipsychotic Cage climbing biology Traditional medicine Behavior Animal business.industry Plant Extracts Noni fruits lcsh:Other systems of medicine General Medicine lcsh:RZ201-999 biology.organism_classification Biting Complementary and alternative medicine Psychotic Disorders Indonesia Climbing Fruit medicine.symptom business Licking medicine.drug Antipsychotic Agents Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine BMC Complementary and Alternative Medicine, Vol 12, Iss 1, p 186 (2012) |
| ISSN: | 1472-6882 |
| Popis: | Background Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing). Methods In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and methamphetamine ( 5 mg/kg, i.p) injection respectively in Swiss albino mice. In chronic studies, (TAHITIAN NONI® Juice, TNJ) was made available freely in daily drinking water at 30, 50 and 100% v/v for 7 days; 30 and 50% v/v for 21 days respectively. On the test day, an equivalent average daily divided dose of TNJ was administered by oral gavage one hour prior to apomorphine treatment. Immediately after apomorphine/ methamphetamine administration, the animals were placed in the cylindrical metal cages and observed for climbing behaviour/ stereotypy and climbing time. Results The acute treatment of MMC (1, 3, 5, 10 g/kg, p.o) significantly decreased the apomorphine-induced cage climbing behaviour and climbing time in mice in a dose dependent manner. The MMC also significantly inhibited methamphetamine-induced stereotypy behaviour and climbing time in mice dose-dependently. The 7 and 21 days treatment of TNJ in drinking water at 50 and 100%v/v significantly alleviated the apomorphine-induced climbing behaviour and climbing time in mice. Conclusions The present study results demonstrated the antidopaminergic effect of Morinda citrifolia Linn. in mice, suggesting that noni has antipsychotic-like activity which can be utilized in the treatment of psychiatric disorders. However further studies are warranted to identify the active principles responsible for the antipsychotic activity of noni. |
| Databáze: | OpenAIRE |
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