Sleep Stage Transitions in Healthy Humans Altered by Central Monoaminergic Antagonist
| Autor: | Yoshiharu Yamamoto, Akifumi Kishi, Zbigniew R. Struzik, Yasushi Inami, Jun Horiguchi, T. Matsumoto, Hideaki Yasuda |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Administration Oral Sleep REM Physiology Health Informatics Polysomnography Non-rapid eye movement sleep Young Adult Health Information Management Reference Values Internal medicine Humans Medicine Ultradian rhythm Slow-wave sleep Advanced and Specialized Nursing Sleep Stages Risperidone medicine.diagnostic_test business.industry Sleep in non-human animals Endocrinology Dopamine Antagonists business K-complex medicine.drug |
| Zdroj: | Methods of Information in Medicine. 49:458-461 |
| ISSN: | 2511-705X 0026-1270 |
| DOI: | 10.3414/me09-02-0032 |
| Popis: | Summary Objectives: Sleep stage transitions constitute one of the key components of the dynamical aspect of sleep. However, neural mechanisms of sleep stage transitions have not, to date, been fully elucidated. We investigate the effects of administrating risperi-done, a central serotonergic and dopaminergic antagonist, on sleep stage transitions inhumans, and also on ultradian rapid-eye-movement (REM) sleep rhythms. Methods: Ten healthy young male volunteers (age: 22 ± 3.7 years) participated in this study. The subjects spent three nights in a sleep laboratory. The first was the adaptation night, and the second was the baseline night. On the third night, the subjects received risperidone (1 mg tablet) 30 min before the polysomnography recording. We measured and investigated transition probabilities between waking, REM and non-REM (stages I–IV) sleep stages. Results: We found that the probability of transition from stage II to stage III was significantly greater for the risperidone night than for the baseline night. We also found that risperidone administration prolonged REM-onset intervals, when compared to the baseline night. Conclusions: We demonstrate that central serotonergic and /or dopaminergic neural transmissions are involved in the regulation of sleep stage transitions from light (stage II) to deep (stage III) sleep, and also in determining ultradian REM sleep rhythms. |
| Databáze: | OpenAIRE |
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