The significance of thymidine phosphorylase expression in colorectal cancer

Autor:	Kenji Katsumata, Tatsunori Baba, Takashi Murohashi, Sohji Takahashi, Tetsuo Sumi, Shinya Yamashita, Kazuhiro Nagashima, Keiichiro Yamamoto, Munetaka Mori, Tatsuto Ashizawa, Kohichiro Katoh, Yasuhisa Koyanagi
Rok vydání:	2001
Předmět:	Adenoma Male Antimetabolites Antineoplastic Cancer Research Pathology medicine.medical_specialty Stromal cell Thymidine phosphorylase activity Adenocarcinoma Biology Deoxycytidine Metastasis Biomarkers Tumor medicine Humans Neoplasm Invasiveness Prodrugs Thymidine phosphorylase Biotransformation Capecitabine Aged Thymidine Phosphorylase Liver Neoplasms Cancer General Medicine Middle Aged Prognosis medicine.disease Neoplasm Proteins Oncology Lymphatic Metastasis Cancer cell Neoplastic Stem Cells Cancer research Female Fluorouracil Stromal Cells Colorectal Neoplasms Floxuridine Immunostaining
Zdroj:	Oncology Reports.
ISSN:	1791-2431 1021-335X
DOI:	10.3892/or.8.1.127
Popis:	We measured thymidine phosphorylase activity in colorectal cancer tissue and conducted immunostaining to investigate enzyme expression in the tumor tissue. The results showed a correlation between staining ratio of thymidine phosphorylase and cancer progression as well as a correlation between enzyme activity and staining ratios of cancer cells and stromal cells. Since enzyme activity levels can be judged by staining ratios, this method may be useful for assessing cancer malignancy.
Databáze:	OpenAIRE
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