Molecular imaging of hypoxia with radiolabelled agents

Autor: Christophe Van De Wiele, Christel Vangestel, Gilles Mees, Rudi Dierckx
Rok vydání: 2009
Předmět:
medicine.medical_specialty
CELL LUNG-CANCER
medicine.medical_treatment
PREDICT RADIOTHERAPY RESPONSE
Review Article
Single-photon emission computed tomography
IODOAZOMYCIN ARABINOSIDE
POSITRON-EMISSION-TOMOGRAPHY
NECK-CANCER
Neoplasms
RADIATION-THERAPY
medicine
Animals
Humans
Radiology
Nuclear Medicine and imaging
F-18 FLUOROMISONIDAZOLE
Hypoxia
Tomography
Emission-Computed
Single-Photon
IN-VIVO EVALUATION
medicine.diagnostic_test
business.industry
Nitroimidazole
Magnetic resonance imaging
General Medicine
Hypoxia (medical)
Molecular Imaging
Radiation therapy
PET
Radiology Nuclear Medicine and imaging
Positron emission tomography
Positron-Emission Tomography
SPECT
GLUCOSE METABOLIC-RATE
Immunohistochemistry
Radiology
Tomography
Radiopharmaceuticals
Molecular imaging
medicine.symptom
business
EXPERIMENTAL MOUSE-TUMORS
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-009-1195-9
Popis: Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant progression. This has led to the development of assays for the detection of hypoxia in patients in order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments. A variety of invasive and non-invasive approaches have been developed to measure tumour oxygenation including oxygen-sensitive electrodes and hypoxia marker techniques using various labels that can be detected by different methods such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), autoradiography and immunohistochemistry. This review aims to give a detailed overview of non-invasive molecular imaging modalities with radiolabelled PET and SPECT tracers that are available to measure tumour hypoxia.
Databáze: OpenAIRE
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