455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with the risk of clinical restenosis in patients with coronary stent placement
| Autor: | Johannes Waltenberger, John J. P. Kastelein, PS Monraats, Pieter A. Doevendans, Robbert J. de Winter, Jamal S. Rana, J. Wouter Jukema, Aeilko H. Zwinderman, Rune R. Frants, Ernst E. van der Wall, René A. Tio, Arnoud van der Laarse, Willem R.P. Agema, Moniek P.M. de Maat |
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| Přispěvatelé: | Hematology, Amsterdam Public Health, Epidemiology and Data Science, Amsterdam Cardiovascular Sciences, Vascular Medicine, Cardiology, Vascular Ageing Programme (VAP) |
| Rok vydání: | 2005 |
| Předmět: |
Male
Risk medicine.medical_specialty STATIN THERAPY medicine.medical_treatment INFLAMMATORY MARKERS HEART-DISEASE Fibrinogen Polymorphism Single Nucleotide coronary stent Coronary Restenosis restenosis Restenosis FACTOR-VII Predictive Value of Tests Internal medicine Coronary stent Clinical endpoint medicine Myocardial Revascularization ARTERY-DISEASE Humans genetics Myocardial infarction Aged biology business.industry C-reactive protein Stent Percutaneous coronary intervention Hematology SERUM-LEVELS Middle Aged medicine.disease C-REACTIVE PROTEIN MYOCARDIAL-INFARCTION CARDIOVASCULAR-DISEASE biology.protein Cardiology Regression Analysis Female Stents ANGIOGRAPHIC RESTENOSIS business medicine.drug Follow-Up Studies |
| Zdroj: | Thrombosis and Haemostasis, 93(3), 564-569. Georg Thieme Verlag Thrombosis and haemostasis, 93(3), 564-569. Schattauer GmbH Thrombosis and Haemostasis, 93(3), 564-569. GEORG THIEME VERLAG KG |
| ISSN: | 0340-6245 |
| Popis: | SummaryThe effect of preprocedural fibrinogen levels on in-stent restenosis is largely unknown. The –455 G/A polymorphism of the fibrinogen β-gene is associated with baseline plasma level or acute phase increase of fibrinogen. Therefore, we hypothesized that there is a relationship between this polymorphism and pre-procedural fibrinogen level and clinical restenosis at follow-up among patients with coronary stent placement. The GENetic DEterminants of Restenosis (GENDER) project is a multicenter follow-up study that enrolled 3,146 consecutive patients after successful percutaneous coronary intervention. A coronary stent was placed in 2,309 patients. Of these, 2,257 (97.7%) patients were successfully genotyped for the –455G/A polymorphism. Plasma fibrinogen levels were measured at baseline in a subpopulation of 623 stented patients with the von Clauss method and patients were grouped into tertiles according to fibrinogen levels. Primary endpoint was target vessel revascularization (TVR); secondary combined endpoint was defined as death presumably from cardiac causes, MI not attributable to another coronary artery than the target vessel, and TVR. No association was observed between the –455G/A polymorphism and TVR or combined endpoint (p=0.99, p=0.97, respectively). Multivariate regression analysis revealed that the risk of TVR and combined endpoint was not higher for patients in the highest tertile for fibrinogen versus the lowest tertile (RR=0.60, 95% CI: 0.26–1.37 for TVR, RR=0.64, 95% CI: 0.29–1.44 for combined endpoint). In conclusion, the presence of –455G/A polymorphism in the fibrinogen β-gene and preprocedural fibrinogen level is not associated with an increased risk of TVR or combined endpoint in a patient population with coronary stent placement. Therefore, these parameters are not worthwhile for stratifying patients at risk for restenosis prestenting. |
| Databáze: | OpenAIRE |
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