Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke

Autor:	Yang Kun Chen, Vincent Mok, Yan Liang, Wai Kwong Tang, Gabor S. Ungvari, Defeng Wang, Chiu Wing Winnie Chu, Eivind Berge, Min Deng
Rok vydání:	2017
Předmět:	Male medicine.medical_specialty Brain Edema Disease 030204 cardiovascular system & hematology Severity of Illness Index Basal Ganglia Brain Ischemia Brain ischemia 03 medical and health sciences 0302 clinical medicine Quality of life Physiology (medical) Internal medicine Severity of illness Centrum semiovale Humans Medicine Pharmacology (medical) Stroke Aged Retrospective Studies Cerebral Cortex Pharmacology medicine.diagnostic_test business.industry Magnetic resonance imaging Retrospective cohort study Original Articles Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Psychiatry and Mental health Quality of Life Female business 030217 neurology & neurosurgery
Zdroj:	CNS Neuroscience & Therapeutics. 23:973-979
ISSN:	1755-5930
DOI:	10.1111/cns.12766
Popis:	SummaryAims This study explored the association between enlarged perivascular spaces (EPVS) and the health-related quality of life (HRQoL) in patients with acute ischemic stroke. Methods This was an observational study of consecutively screened patients with acute ischemic stroke from March 2010 to March 2015. EPVS were rated in the basal ganglia and the centrum semiovale with a validated scale. The HRQoL was assessed 3 months after the stroke onset using the Stroke-Specific Quality of Life (SSQoL). Linear regression models were used to study the association between EPVS and HRQoL. Results The study included 648 patients (mean age 65.8 years; 40.0% women) with mild to moderately severe stroke (median NIHSS score 2), of whom 640 (98.8%) exhibited signs of small vessel disease. The median EPVS scores in the basal ganglia and the centrum semiovale were 1 each. In linear regression analysis, EPVS in the basal ganglia were associated with a lower total SSQoL score (P = 0.02) and lower mobility (P = 0.01), mood (P = 0.03), and self-care (P
Databáze:	OpenAIRE
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