Unilateral AMPA lesions of nucleus basalis magnocellularis induce a sensorimotor deficit which is differentially altered by arecoline and nicotine
| Autor: | J.D. Sinden, Fuad Abdulla, J. D. Stephenson, M.-R. Calaminici |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Nicotine Sensory Receptor Cells Arecoline Stimulation Nucleus basalis Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Substantia Innominata Internal medicine Orientation Mecamylamine Muscarinic acetylcholine receptor medicine Animals Receptors Cholinergic Dominance Cerebral alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Basal forebrain Afferent Pathways Brain Mapping Rats Smell Amphetamine Endocrinology chemistry Cholinergic Fibers Hexamethonium Stereotyped Behavior Neuroscience Psychomotor Performance medicine.drug |
| Zdroj: | Behavioural brain research. 60(2) |
| ISSN: | 0166-4328 |
| Popis: | One week after unilateral alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) lesions of nucleus basalis magnocellularis, rats showed significant lateralised bias in spontaneous turning and in turning induced by tail pinch or by placing the rat on a 45 degrees grid. Turning was biased to the lesioned side and this side also showed increased responsiveness to pin-prick stimulation of the skin (somaesthesia), snout and whisker stimulation and ammonia olfaction. Arecoline (0.5 mg/kg), at a dose which did not affect responses to sensorimotor stimulation in sham-operated rats, corrected the lesion-induced biased turning to tail pinch and the 45 degrees grid test and reduced the bias in the open field. In contrast, nicotine (0.05 mg/kg), at a dose which also did not substantially affect responses to sensorimotor stimulation in sham-operated rats, switched the lesion-induced turning bias towards the contralateral side. Neither cholinoceptor agonist reduced the lesion-induced increased sensory responsiveness. The effects of nicotine were blocked by the centrally acting nicotinic antagonist, mecamylamine (1.0 mg/kg), but not by hexamethonium (1.0 mg/kg), or ondansetron (0.01 mg/kg). Amphetamine (up to 1.0 mg/kg) did not affect the lesion-induced motor asymmetry. The results confirm that the basal forebrain cholinergic system plays a role in sensorimotor cortical functions, but suggest different functional roles for muscarinic and nicotinic receptors. |
| Databáze: | OpenAIRE |
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