Expression of Concern: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta
| Autor: | Pamela Murphy, Fusun Kilic, Luc Maroteaux, Curtis L. Lowery, Yicong Li, Asli Ahmed, Ruston Koonce, Nafisa K. Dajani, Imelda N. Odibo, Drucilla J. Roberts, Anthonya Cooper |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases business.industry nutritional and metabolic diseases Molecular Bases of Disease Cell Biology Insulin regulation medicine.disease Biochemistry Expressions of Concern female genital diseases and pregnancy complications Gestational diabetes medicine.anatomical_structure Endocrinology Internal medicine Placenta embryonic structures Medicine Platelet business Molecular Biology reproductive and urinary physiology |
| Popis: | Earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the trophoblast in placenta. Because of the defect on insulin receptor (IR) in the trophoblast of the gestational diabetes mellitus (GDM)-associated placenta, SERT is found entrapped in the cytoplasm of the GDM-trophoblast. SERT is encoded by the same gene expressed in trophoblast and platelets. Additionally, alteration in plasma 5-HT levels and the 5-HT uptake rates are associated with the aggregation rates of platelets. Therefore, here, we investigated a novel hypothesis that GDM-associated defects in platelet IR should change their 5-HT uptake rates, and this should be a leading factor for thrombosis in GDM maternal blood. The maternal blood and the placentas were obtained at the time of cesarean section from the GDM and non-diabetic subjects (n = 6 for each group), and the platelets and trophoblasts were isolated to determine the IR activity, surface level of SERT, and their 5-HT uptake rates. |
| Databáze: | OpenAIRE |
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