Expression of DDR1 and DVL1 in invasive ductal and lobular breast carcinoma does not correlate with histological type, grade and hormone receptor status
| Autor: | Noraidah Masir, Fereshteh Ameli, Isa Mohd Rose |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Epidemiology Receptor ErbB-2 Lobular Breast Carcinoma Dishevelled Proteins Estrogen receptor Breast Neoplasms Biology Immunoenzyme Techniques Discoidin Domain Receptor 1 Progesterone receptor Carcinoma medicine Biomarkers Tumor Drosophila Proteins Humans skin and connective tissue diseases Receptor Adaptor Proteins Signal Transducing Neoplasm Staging DDR1 Carcinoma Ductal Breast Public Health Environmental and Occupational Health Receptor Protein-Tyrosine Kinases Middle Aged medicine.disease Phosphoproteins Prognosis body regions Carcinoma Lobular Cross-Sectional Studies Oncology Receptors Estrogen Hormone receptor Cancer research Female Neoplasm Grading Breast carcinoma Receptors Progesterone Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(6) |
| ISSN: | 2476-762X |
| Popis: | Background Invasive ductal (IDC) and lobular (ILC) carcinomas are the common histological types of breast carcinoma which are difficult to distinguish when poorly differentiated. Discoidin domain receptor (DDR1) and Drosophila dishevelled protein (DVL1) were recently suggested to differentiate IDC from ILC. Objectives To assess the expression of DDR1 and DVL1 and their association with histological type, grading and hormonal status of IDC and ILC. Materials and methods This cross sectional study was conducted on IDC and ILC breast tumours. Tumours were immunohistochemically stained for (DDR1) and (DVL1) as well as estrogen receptor (ER), progesterone receptor (PR) and C-erbB2 receptor. Demographic data including age and ethnicity were obtained from patient records. Results A total of 51 cases (30 IDCs and 21 ILCs) were assessed. DDR1 and DVL1 expression was not significantly associated with histological type (p=0.57 and p=0.66 respectively). There was no association between DDR1 and DVL1 expression and tumour grade (p=0.32 and p=1.00 respectively), ER (p=0.62 and 0.50 respectively), PR (p=0.38 and p=0.63 respectively) and C-erbB2 expression (p=0.19 and p=0.33 respectively) in IDC. There was no association between DDR1 and DVL1 expression and tumour grade (p=0.52 and p=0.33 respectively), ER (p=0.06 and p=0.76 respectively), PR (p=0.61 and p=0.43 respectively) and C-erbB2 expression (p=0.58 and p=0.76 respectively) in ILC. Conclusions This study revealed that DDR1 and DVL1 are present in both IDC and ILC regardless of the tumour differentiation. More studies are needed to assess the potential of these two proteins in distinguishing IDC from ILC in breast tumours. |
| Databáze: | OpenAIRE |
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