Beneficial effects of Salvia officinalis essential oil on vanadium-induced testicular injury, DNA damage and histological alterations in Wistar rats
| Autor: | Fatma Ghorbel Koubaa, Mariem Chaâbane, Nour Chiab, Hajer Jdidi, Mediha Sefi, Ons Boudawara, Mouna Turki, Radhia Gargouri Bouzid, Tahia Boudawara Sellami, Fatma Makni Ayadi, Abdelfattah El Feki |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Metals and Alloys Vanadium General Biochemistry Genetics and Molecular Biology Antioxidants Rats Biomaterials Oxidative Stress Seeds Oils Volatile Animals Testosterone Lipid Peroxidation Saline Solution Rats Wistar General Agricultural and Biological Sciences Reactive Oxygen Species Salvia officinalis DNA Damage |
| Zdroj: | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 35(5) |
| ISSN: | 1572-8773 |
| Popis: | Vanadium has been shown to catalyze the generation of reactive oxygen species. Since free radical production and lipid peroxidation are potentially important mediators in testicular physiology and pathophysiology, the present study was conducted to elucidate vanadium-induced oxidative damage in rat testis and the ameliorative role of Salvia officinalis essential oil (SEO) against the adverse effects of this heavy metal. Adult male Wistar rats were treated daily during 10 days either with ammonium metavanadate (5 mg/kg bw, intraperitoneally), SEO (15 mg/kg bw, orally) or their combination. A group of rats receiving daily a saline solution served as a negative control. Vanadium treatment induced a significant decrease in body and reproductive organ weights, serum testosterone level and sperm number and motility. An increase in lipid peroxidation and protein oxidation as well as a marked inhibition in the activities of antioxidant enzymes in the testes and seminal vesicles indicated the occurrence of oxidative stress after vanadium toxicity. Histopathological changes in testis and seminal vesicles were also observed following vanadium administration. However, co-administration of SEO to vanadium-treated rats resulted in an appreciable improvement of these parameters, emphasizing the therapeutic effects of SEO. It can be suggested that SEO mitigates vanadium-induced reproductive damage due to its antioxidant capacity. Thus, we can hypothesize that SEO supplementation could protect against vanadium poisoning. |
| Databáze: | OpenAIRE |
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