PERSISTENT ORGANOCHLORINE POLLUTANTS IN OBESE WOMEN AFTER DIET INDUCED WEIGHT LOSS: FIVE YEARS FOLLOW UP STUDY

Autor: Luděk Müller, Jan Rosmus, Kateřina Kovářová, Dana Müllerová, Jana Dvořáková, Dagmar Matějková
Rok vydání: 2015
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Zdroj: ResearcherID
Scopus-Elsevier
ISSN: 1210-7778
Popis: INTRODUCTIONPersistent organochlorine pollutants (POPs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are synthetic chemicals that have been released into the environment in hundreds of metric tons for many years and have been used in diverse applications such as industry and agriculture. Although they were banned in most countries, their residues are still widespread in the environment. Because of their high lipophilicity and structural stability, they still can be found accumulated in biological systems. They show a carcinogenic and an endocrine disruption potential. Recently, based on epidemiological studies, there has been concern about their speculated association with metabolic disturbances like diabetes mellitus type 2, rheumatoid arthritis, disturbances of cognitive function, etc. Contaminated food, especially fatty fish, meat and milk products, is still a main source of the exposure of general population (1).Among chlorinated pesticides, p,p'-DDT has been used most extensively. Its metabolite p,p'-DDE together with hexachlorocyclobenzene (HCB) are, at the present day, the most frequently prevalent residues in the adipose tissue of humans (2).PCBs form a subgroup of halogenated aromatic hydrocarbons. There are theoretically 209 single congeners. They have been used, to a great extent, in diverse technical applications from the 1930s to the 1970s (3). Despite production bans in many industrial countries in the 1970s and 1980s, about 113 different PCB congeners were still detectable in the environment in 1998 (4). Their concentration in human tissue is generally monitored by using examinations of human breast milk and data from Europe show their decreased concentration. 'Non-dioxin-like' PCB 153, 138, and 180 are the main congeners which show the highest concentration and are most frequently found in breast milk (5). In the former Czechoslovakia, PCB was marketed as technical mixtures under the trade name "Delor" produced in the amount of about 21,500 tons in Eastern Slovakia from 1959 to 1984, when the production was finally abolished (6). About 11,600 tons were used inside the former Czechoslovakia (7). Therefore, the industrial areas of the Czech Republic have one of the highest PCB burdens of all European countries (8).After human exposure, POPs are accumulated in the body, especially in the adipose tissue. They have relatively long halflives before disappearing from the tissue or from the body. The variability of the stored amount depends on dietary exposure (food habits, and the quality and quantity of POPs in available food) and on individual disposition to store these substances (genetic traits and size of adipose tissue and its dynamic changes) (9). Their distribution in the body is affected by changes in body weight. Weight loss resulted in an acute increase of their concentration in reduced adipose tissue, brain, and serum/plasma without changing the total amount, as it was documented in case of hexachlorocyclohexane (HCH) (10). However, dramatic weight loss, which occurred as a consequence of bariatric surgery treatment, showed not only an increased level of serum and adipose tissue POPs concentrations together with a reduced amount of white adipose tissue, but a decreased total body burden for POPs after 12 months post-surgery as well (11). The objective of our study was to analyze in five year follow up study the development of plasma POPs levels in obese women in relationship to their weight loss success, caused by restrictive diet regimen.MATERIALS AND METHODSTwenty obese adult women, aged 25-73 years (BMI > 30 kg/ m2) were randomly selected from the patients of the Centre for Obesity Treatment (Faculty Hospital in Pilsen, Czech Republic) during their first visit in 2006. Informed consent was obtained from all patients involved in the study. Anthropometry: body weight (BW) and height were measured, and a plasma analysis of 7 POPs (p,p'-DDE, p,p'-DDT, HCB, HCH s, PCB 153, 138, 180) was performed in all the subjects. …
Databáze: OpenAIRE
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