Co-administration of Selenium Nanoparticles and Metformin Abrogate Testicular Oxidative Injury by Suppressing Redox Imbalance, Augmenting Sperm Quality and Nrf2 Protein Expression in Streptozotocin-Induced Diabetic Rats
| Autor: | Stephen O. Okori, Olasehinde Olusanya, Kebe E. Obeten, Richard C. Ehiri, Chukwuma J. Chukwu, Nworie Okoro, Azubuike P. Ebokaiwe, Ebuka E David |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty NF-E2-Related Factor 2 Endocrinology Diabetes and Metabolism Clinical Biochemistry 010501 environmental sciences medicine.disease_cause 01 natural sciences Biochemistry Streptozocin Diabetes Mellitus Experimental Inorganic Chemistry Selenium 03 medical and health sciences Internal medicine Diabetes mellitus Testis medicine Animals Testosterone 0105 earth and related environmental sciences 0303 health sciences business.industry 030302 biochemistry & molecular biology Biochemistry (medical) General Medicine medicine.disease Streptozotocin Spermatozoa Sperm Metformin Prolactin Rats Oxidative Stress Endocrinology Nanoparticles business Oxidation-Reduction Oxidative stress Hormone medicine.drug |
| Zdroj: | Biological Trace Element Research. 198:544-556 |
| ISSN: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-020-02082-2 |
| Popis: | Selenium nanoparticles (SeNPs) and metformin (Met) elicit individually protective effects against testicular oxidative injury in diabetic rats. However, the combined effects of both compounds have not been investigated. We investigated the effects of SeNPs and Met individual/co-treatment on testicular oxidative injury in diabetic rats. Diabetes was induced by a single intraperitoneal administration of streptozotocin (STZ-40 mg/kg bwt). The rats were equally divided into 6 groups: Group one—non-diabetic; group two—diabetic untreated; and group six—non-diabetic received citrate buffer (2 mL/kg bwt), while group three, four, and five received SeNPs (0.1 mg/kg bwt), Met (50 mg/kg bwt), and SeNPs/Met combined respectively, for 42 days. Results revealed that SeNPs, as well as Met treatment significantly (p |
| Databáze: | OpenAIRE |
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