Edema as a Very Early Marker for Acute Myocardial Ischemia
| Autor: | Cheryl Meek, Matthias G. Friedrich, Myra S Cocker, John V. Tyberg, Hassan Abdel-Aty |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology business.industry Unstable angina Infarction Magnetic resonance imaging 030204 cardiovascular system & hematology medicine.disease Troponin 030218 nuclear medicine & medical imaging 3. Good health 03 medical and health sciences 0302 clinical medicine Coronary occlusion Internal medicine Edema Circulatory system medicine biology.protein Cardiology Myocardial infarction medicine.symptom business Cardiology and Cardiovascular Medicine |
| Zdroj: | Journal of the American College of Cardiology. 53(14):1194-1201 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2008.10.065 |
| Popis: | Objectives This study was designed to determine whether imaging myocardial edema would identify acute myocardial ischemia before irreversible injury takes place. Background Early identification of acute myocardial ischemia is a diagnostic challenge. Methods We studied 15 dogs with serial T2-weighted and cine imaging at baseline, during transient coronary occlusion of up to 35 min, and after reperfusion in a 1.5-T magnetic resonance imaging system. Late gadolinium enhancement and troponin measurements were used to assess for the presence of irreversible injury. Myocardial water content was measured to assess myocardial edema. Results We consistently observed a transmural area of high T2signal intensity matching areas with new onset regional akinesia 28 ± 4 min after experimental coronary artery occlusion. At this time, the contrast-to-noise ratio between the ischemic and remote myocardium had significantly increased from 1.0 ± 2.0 to 12.8 ± 9.6 (p Conclusions We provide the first evidence that T2-weighted cardiovascular magnetic resonance imaging of edema detects acute ischemic myocyte injury before the onset of irreversible injury. T2-weighted cardiovascular magnetic resonance imaging may serve as a very useful diagnostic marker in clinical settings such as unstable angina or evolving infarction. |
| Databáze: | OpenAIRE |
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