Sex differences of continuous positive airway pressure treatment on flow-mediated dilation in patients with obstructive sleep apnea syndrome
| Autor: | Paul Zarogoulidis, Konstantinos Kostopoulos, Christoforos Kostopoulos, Antonis Papaiwannou, Georgia Pitsiou, John Organtzis, Athanasios Panoutsopoulos, Sofia Lampaki, Georgia Trakada, Anastasios Kallianos, Chrysanthi Papamichail, Christoforos Mermigkis, Ioannis Nikolopoulos, Ioannis Kokkonouzis |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Diastole obstructive sleep apnea syndrome Risk Factors CPAP Internal medicine Medicine Humans Continuous positive airway pressure Endothelial dysfunction Aged Original Research Glycated Hemoglobin Inflammation glucose control Sex Characteristics Sleep Apnea Obstructive biology Continuous Positive Airway Pressure business.industry C-reactive protein blood pressure General Medicine Middle Aged medicine.disease Pulse pressure respiratory tract diseases Obstructive sleep apnea Blood pressure Endocrinology C-Reactive Protein Clinical Interventions in Aging Ambulatory biology.protein Cardiology Female Endothelium Vascular Geriatrics and Gerontology Inflammation Mediators business CRP |
| Zdroj: | Clinical Interventions in Aging |
| ISSN: | 1178-1998 |
| Popis: | Anastasios Kallianos,1 Athanasios Panoutsopoulos,1 Christoforos Mermigkis,2 Konstantinos Kostopoulos,1 Chrysanthi Papamichail,1 Ioannis Kokkonouzis,3 Christoforos Kostopoulos,1 Ioannis Nikolopoulos,4 Antonis Papaiwannou,5 Sofia Lampaki,5 John Organtzis,5 Georgia Pitsiou,5 Paul Zarogoulidis,5 Georgia Trakada1 1Sleep Disorders Unit, Department of Clinical Therapeutics, “Alexandra” General Hospital, Athens School of Medicine, 2Sleep Disorders Unit, Pulmonary Department, 401 General Army Hospital, 3Pulmonary Department, 251 Hellenic Air Force General Hospital, 4Sleep Disorders Unit, “Sotiria” Regional Chest Diseases Hospital of Athens, Athens, Greece; 5Pulmonary Department – Oncology Unit, George Papanikolaou General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, GreeceIntroduction: There is growing research evidence suggesting the presence of endothelial dysfunction and systemic inflammation in patients with obstructive sleep apnea syndrome (OSAS). Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS; nonetheless, the effects of CPAP on the aforementioned pathophysiologic pathways as well as on the systemic disease that result or coexist with the OSAS remain elusive.Aim: To assess the effect of 3-month CPAP therapy on endothelial-dependent dilation, plasma levels of inflammatory markers, blood pressure (BP), and glucose control on male and female patients with OSAS.Methods: Our study group consisted of 40 (24 males and 16 females) patients with no prior history of cardiovascular disease, with an apnea–hypopnea index ≥15, who were assigned to receive CPAP treatment. Measurements of flow-mediated dilation (FMD), 24-hour ambulatory BP, and blood analysis were performed at baseline and 3months after CPAP therapy.Results: Baseline FMD values were negatively correlated with the apnea–hypopnea index (r=−0.55, P=0.001). After 3months of CPAP, there was an increase in the FMD values (5.40%±2.91% vs 3.13%±3.15%, P |
| Databáze: | OpenAIRE |
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