Cytomegalovirus (CMV) and human immunodeficiency virus (HIV) burden, CMV end-organ disease, and survival in subjects with advanced HIV infection (AIDS Clinical Trials Group Protocol 360)
| Autor: | Adriana Weinberg, Michelle A. Kendall, Alejo Erice, M. S. Hirsch, Bruce Polsky, Courtney N. Tierney, Angela M. Caliendo |
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| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Human cytomegalovirus Adult Male Cytomegalovirus HIV Infections medicine.disease_cause Antiviral Agents Virus Herpesviridae Betaherpesvirinae medicine Humans Prospective Studies Sida biology AIDS-Related Opportunistic Infections business.industry virus diseases HIV Middle Aged Viral Load biology.organism_classification medicine.disease Virology CD4 Lymphocyte Count Survival Rate Infectious Diseases Lentivirus Immunology Cytomegalovirus Infections DNA Viral RNA Viral Female Viral disease business Follow-Up Studies |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 37(4) |
| ISSN: | 1537-6591 |
| Popis: | We undertook a prospective study to analyze cytomegalovirus (CMV) end-organ disease (EOD) in subjects with advanced human immunodeficiency virus (HIV) infection. Of 403 individuals without prior CMV EOD who were followed up for a median of 151 weeks, 56 died and 21 developed CMV EOD. Twenty of the subjects with CMV EOD had CD4 cell counts of ≤50 cells/mm 3 and HIV RNA level of >10,000 copies/mL of plasma at baseline; in these 20 subjects, an increase of CMV DNA level to greater than the quantification limits was associated with CMV EOD. A CD4 cell count of ≤100 cells/mm 3 and an HIV RNA level of >10,000 copies/ mL of plasma at baseline, a CMV DNA level of >200 copies/mL of blood during follow-up, or development of CMV EOD were all associated with decreased survival. HIV-infected subjects with CD4 cell counts of ≤50 cells/mm 3 and HIV RNA levels of >10,000 copies/mL of plasma should have blood fractions screened for CMV DNA; if CMV DNA is detected, CMV prophylaxis might be considered. |
| Databáze: | OpenAIRE |
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