Reusable Nano-Zirconia-Catalyzed Synthesis of Benzimidazoles and Their Antibacterial and Antifungal Activities
| Autor: | Naushad Ahmad, M.V. Basaveswara Rao, G. Rajasekhar Reddy, Nalla Krishna Rao, Fadwa Albalawi, Tentu Manohra Naidu, Faheem Ahmed, Suliman Y Alomar, Tentu Nageswara Rao, Ravi Kumar Cheedarala |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Benzimidazole
Antifungal Agents nano-ZrO2 Materials science XRD Pharmaceutical Science Organic chemistry Crystal structure 010402 general chemistry 01 natural sciences Microanalysis Catalysis Article benzimidazole Analytical Chemistry chemistry.chemical_compound QD241-441 o-Phenylenediamine Drug Discovery Nano Cubic zirconia Physical and Theoretical Chemistry aryl aldehydes 010405 organic chemistry o-phenylenediamine technology industry and agriculture Combinatorial chemistry Anti-Bacterial Agents 0104 chemical sciences chemistry Chemistry (miscellaneous) Nanoparticles Molecular Medicine Benzimidazoles Zirconium Crystallite |
| Zdroj: | Molecules, Vol 26, Iss 4219, p 4219 (2021) Molecules Volume 26 Issue 14 |
| ISSN: | 1420-3049 |
| Popis: | In this article, a zirconia-based nano-catalyst (Nano-ZrO2), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole drugs in a one-pot method. All synthesized materials were characterized using 1HNMR, 13CNMR, and LC-MS spectroscopy as well as microanalysis data. Furthermore, the synthesis of nano-ZrO2 was processed using a standard hydrothermal technique in pure form. The crystal structure of nano-ZrO2 and phase purity were studied, and the crystallite size was calculated from XRD analysis using the Debye–Scherrer equation. Furthermore, the antimicrobial activity of the synthesized benzimidazole drugs was evaluated in terms of Gram-positive, Gram-negative, and antifungal activity, and the results were satisfactory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|