A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology
| Autor: | Gregory Vuillaume, Blaine Phillips, Julia Hoeng, Emilija Veljkovic, Ulrike Kogel, Celine Merg, Davide Sciuscio, Subash Krishnan, Patrick Vanscheeuwijck, Tom Lee, Nikolai V. Ivanov, Florian Martin, Patrice Leroy, Bjoern Titz, Ashraf Elamin, Walter K. Schlage, Manuel C. Peitsch |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Hot Temperature Respiratory System Clinical Chemistry Tests 010501 environmental sciences Pharmacology Toxicology medicine.disease_cause 01 natural sciences Rats Sprague-Dawley Nicotine 03 medical and health sciences Smoke Tobacco Toxicity Tests medicine Animals Respiratory system Sidestream smoke 0105 earth and related environmental sciences Aerosols Inhalation exposure Inhalation Exposure Hematologic Tests Inhalation business.industry Body Weight Feeding Behavior Organ Size General Medicine Carbon Nasal Mucosa 030104 developmental biology medicine.anatomical_structure Toxicity Female Irritation business Bronchoalveolar Lavage Fluid Biomarkers Food Science Respiratory tract medicine.drug |
| Zdroj: | Food and Chemical Toxicology. 116:388-413 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2018.04.015 |
| Popis: | Within the framework of a systems toxicology approach, the inhalation toxicity of aerosol from a novel tobacco-heating potentially modified risk tobacco product (MRTP), the carbon-heated tobacco product (CHTP) 1.2, was characterized and compared with that of mainstream smoke (CS) from the 3R4F reference cigarette in a 90-day nose-only rat inhalation study in general accordance with OECD TG 413. CHTP1.2 is a heat-not-burn product using a carbon heat source to produce an aerosol that contains nicotine and tobacco flavor. At equal or twice the nicotine concentration in the test atmospheres, inhalation of CHTP1.2 aerosol led to a significantly lower exposure to harmful constituents and induced less respiratory tract irritation, systemic, and pathological effects compared with CS. Nasal epithelial changes were less pronounced in the CHTP1.2- than in the CS-exposed groups and reverted in the nicotine concentration-matched group after a recovery period. Lung inflammation was minimal in the CHTP1.2-treated groups compared with the moderate extent seen in the 3R4F groups. Many other toxicological endpoints evaluated did not show CHTP1.2 aerosol exposure-related effects, and no effects not seen for 3R4F were observed. These observations were consistent with findings from previous studies in which rats were exposed to MRTP aerosols containing similar nicotine concentrations. |
| Databáze: | OpenAIRE |
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