Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression
| Autor: | Florian Holsboer, Hans Brunner, Elisabeth Friess, Christoph J. Lauer, D. A. Schmid, Manfred Uhr, Alexander Yassouridis |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Hydrocortisone Polysomnography Pituitary-Adrenal System Sleep REM Growth Hormone-Releasing Hormone Dexamethasone Receptors Glucocorticoid Internal medicine medicine Humans Circadian rhythm Biological Psychiatry Aged Slow-wave sleep Depressive Disorder Major Human Growth Hormone Electroencephalography Middle Aged Sleep in non-human animals Psychiatry and Mental health Endocrinology medicine.anatomical_structure Delta Rhythm Female Sleep Stages Sleep Psychology hormones hormone substitutes and hormone antagonists Glucocorticoid Hypothalamic–pituitary–adrenal axis medicine.drug Hormone |
| Zdroj: | Journal of Psychiatric Research. 42:991-999 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2007.12.003 |
| Popis: | Acute administration of cortisol increases non-rapid-eye movement (non-REM) sleep, suppresses rapid-eye movement (REM) sleep and stimulates growth hormone (GH) release in healthy subjects. This study investigates whether cortisol has similar endocrine and electrophysiological effects in patients with depression who typically show a pathological overactivity of the hypothalamus-pituitary-adrenal (HPA) system. Fifteen depressed inpatients underwent the combined dexamethasone/corticotropin-releasing hormone test followed by three consecutive sleep EEG recordings in which the patients received placebo (saline) and hourly injections of cortisol (1mg/KG BW). Cortisol increased duration and intensity of non-REM sleep in particular in male patients and stimulated GH release. The activity of the HPA axis appeared to influence the cortisol-induced effects on non-REM sleep and GH levels. Stimulation of delta sleep was less pronounced in patients with dexamethasone nonsuppression. In contrast, REM sleep parameters were not affected by the treatment. These data demonstrate that the non-REM sleep-promoting effects of acute cortisol injections observed in healthy controls could be replicated in patients with depression. Our results suggest that non-REM and REM sleep abnormalities during the acute state of the disease are differentially linked to the activity of the HPA axis. |
| Databáze: | OpenAIRE |
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