Mucosal [SIgA] and serum [IgG] immunologic responses in the community after a single intra-nasal immunization with a new inactivated trivalent influenza vaccine
| Autor: | Miriam Schlesinger, Evgenia Greenbaum, Avraham Morag, Zichria Zakay-Rones, Arthur Furst, Brendon Stewart, Alexander Kiderman, Reuven Levy |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Trivalent influenza vaccine Adolescent Mucous membrane of nose Antibodies Viral Placebo Immunoglobulin G Immune system Humans Medicine Prospective Studies Child Administration Intranasal Hemagglutination assay General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Middle Aged Virology Nasal Mucosa Titer Infectious Diseases Immunization Influenza Vaccines Immunoglobulin A Secretory Immunology biology.protein Molecular Medicine Female business |
| Zdroj: | Vaccine. 20:1232-1239 |
| ISSN: | 0264-410X |
| Popis: | Influenza morbidity affects entire populations, imposing an enormous burden in economic terms from working days lost. Protection afforded by current vaccines is often unsatisfactory and many individuals remain averse to injections. To counter these drawbacks, we tested an inactive intra-nasal trivalent influenza vaccine on 182 vaccinated and 92 placebo subjects in the community. On study completion 73 and 66% of the subjects were immune to the vaccine's two A strains, 40% (> or=1:40) and 65% (> or=1:20) to its B strain; 30-40% demonstrated a 4x hemagglutination inhibition (HAI) titer increase; GMT titers increased 2.2-2.5x. About 50% of those initially non-immune became immune. A local antibody response to the three vaccine strains was recorded in 31-44% of vaccinees in which 57, 68 and 54% exhibited a mucosal and/or serum antibody response to the A/Johannesburg, A/Nanchang and B/Harbin strains, respectively. A higher dose (40mg) of A/Johannesburg in the vaccine did not influence response. The new vaccine was safe, without side-effects, and offered reasonable protection after one dose. It could thus play an important role in increasing enrollment into immunization programs. |
| Databáze: | OpenAIRE |
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